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Mary Elaine Eyster, M.D., F.A.C.P.

Distinguished Professor of Medicine and Pathology Director, Hemophilia Program Medical Director, Hemostasis and Special Coagulation Laboratories

Office Information

Penn State Cancer Institute
500 University Drive, CH46
Hershey, PA 17033
Tel: 800-243-1455 / 717-531-8401 Fax: 717-531-0647



Patient Services Provided

Benign Hematology Bleeding and Clotting Disorders Thrombosis Anemia

Practice Locations

Biographical Information

Dr. Eyster received her medical degree from Duke University, School of Medicine in 1960 and completed a residency in Internal Medicine at New York Hospital-Cornell Medical Center (currently known as New York-Presbyterian/Weill Cornell Medical Center) in 1963. She remained at New York Hospital-Cornell Medical Center, where she completed a fellowship in hematology in 1966.

Dr. Eyster joined the medical staff at Penn State Hershey Medical Center in 1970. She served as Chief of the Division of Hematology from 1973-1995, and has been the Director of the Hemophilia Program and Medical Director of the Special Hematology/Coagulation laboratory since 1973. Her clinical and laboratory interests are disorders of bleeding and clotting, and the anemias.

Professional Education

Fellowship, Hematology, New York-Presbyterian/Weill Cornell Medical Center (1966) Residency, Internal Medicine, New York-Presbyterian/Weill Cornell Medical Center (1963) M.D., Duke University, School of Medicine (1960)

Research Interests

Over the past 30 years, Dr. Eyster’s  research has focused on the epidemiology and natural history of transfusion acquired HIV and Hepatitis C virus infections in persons with hemophilia.

Dr. Eyster's current research interest is inhibitor development in persons with hemophilia.


Gadalla SM, Preiss LR, Eyster ME, Goedert JJ
Correlates of high hepatitis C virus RNA load in a cohort of HIV-negative and HIV-positive individuals with hemophilia.
Journal of Viral Hepatitis, 2010 Mar 8 [Epub ahead of print].
Eyster, ME
Coping with the HIV epidemic 1982-2007: 25-year outcomes of the Hershey Haemophilia Cohort.
Haemophilia 14, 697-202, 2008.
Goedert JJ, Eyster ME, Lederman MM, Mandalaki T, De Moerloose P, White GC, et al, for the Multicenter Hemophilia Cohort Study
End-stage liver disease in persons with hemophilia and transfusion-associated infections.
Blood 100: 1584-1589, 2002.
Goedert JJ, Hatzakis A, Maloney EM, Eyster ME, for the Multicenter Hemophilia Cohort Study.
Increased liver decompensation risk with atypical hepatitis C virus antibody levels.
Journal of Infectious Diseases, 182(2): 590-594, 2000.
Eyster ME, Fried M, Di Bisceglie A, Goedert JJ
Increasing HCV RNA levels in hemophiliacs: Relationship to HIV infection and liver disease.
Blood 84: 1020-1023, 1994.
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Honors and Awards

Distinguished Professorship in Medicine and Pathology Distinguished Medical Alumnus Award Duke University 2011