Thomas P. Loughran, Jr., M.D.Professor of Medicine Director, Penn State Hershey Cancer Institute
Penn State Hershey Cancer Institute
500 University Drive
Hershey, PA 17033
Tel: 800-243-1455 / 717-531-6585 Fax: 717-531-0429
Patient Services Provided
LGL Leukemia Lymphoma Leukemia Hematologic Malignancies Cancer Screening and Treatment
Upon completing his Biology degree at Ursinus College in 1975, Dr. Thomas Loughran continued on to Hahnemann Medical School where he earned his medical degree, graduating in 1979. He then pursued both his internship and residency at Thomas Jefferson University Hospital, followed by a successful fellowship at the Fred Hutchinson Cancer Research Center at the University of Washington.
Throughout the 80’s and early 90’s, Dr. Loughran worked in the Clinical Research Division at the Fred Hutchinson Cancer Research Center under the leadership of Nobel Laureate, Dr. E.D. Thomas. He then returned back east and spent time as a professor of medicine and Associate Director of the Bone Marrow Transplant Program at the SUNY Health Science Center, and Chief of Hematology at the Veteran's Administration Medical Center in Syracuse, New York. He then went on to become the Program Leader of Hematologic Malignancies at the H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida in Tampa. Dr. Loughran is the first Director of the Penn State Hershey Cancer Institute, appointed in 2003.
Dr. Loughran was instrumental in discovering a new hematologic malignancy which he termed large granular lymphocyte (LGL) leukemia. Dr. Loughran’s career path has been a testament to translational research – with his clinical observations leading to discoveries in the laboratory, and his laboratory research contributing to improved clinical treatments. Dr. Loughran has had continuous funding for his research since his fellowship in 1985.
Fellowship, Medical Oncology, Fred Hutchinson Cancer Research Center (1985) Residency, Internal Medicine, Thomas Jefferson University Hospital (1982) Internship, Internal Medicine, Thomas Jefferson University Hospital (1980) M.D., Hahnemann University (1979)
In addition to his research interest in large granular lymphocyte (LGL) leukemia, Dr. Loughran's research interests include retrovirus infections and cellular immunity. Among his many areas of expertise are hematologic neoplasms and bone marrow transplantation. Dr. Loughran has published in over 190 publications in leading journals, including Proceedings of the National Academy of Sciences of the United States of America, Blood, Annals of Internal Medicine, New England Journal of Medicine, and Journal of Clinical Oncology.
Yang J, Liu X, Nyland SB, Zhang R, Ryland LK, Broeg K, Baab KT, Jarbadan NR, Irby R, Loughran TP, Jr
Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway.
Blood, 2009. PMID: 19880494 Zhang R, Shah MV, Yang J, Nyland SB, Liu X, Yun JK, Albert R, Loughran TP, Jr
Network model of survival signaling in large granular lymphocyte leukemia.
Proceedings of the National Academy of Sciences of the United States of America, 105:16308-13, 2008. PMID: 18852469 Epling-Burnette PK, Sokol L, Chen X, Bai F, Zhou J, Blaskovich M, Melchert M, Ku E, Zou J, Painter J, Edwards T, Moscinski L, Yoder J, Djeu J, Sebti S, Loughran TP, Jr, Wei S
Clinical improvement by Farnesyltransferase inhibition in NK large granular lymphocyte leukemia associated with imbalanced NK receptor signaling.
Blood. 112:4694-8, 2008. Shah MV, Zhang R, Irby R, Kothapalli R, Liu X, Arrington T, Frank B, Lee NH, Loughran TP, Jr
Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes.
Blood. 112:770-81, 2008. Loughran TP, Jr, Kadin ME, Starkebaum G, Abkowitz JL, Clark EA, Disteche C, Lum LG, Slichter SJ
Leukemia of large granular lymphocytes: Association with clonal chromosomal abnormalities and auto-immune neutropenia, throbocytopenia and hemolytic anemia
Annals of Internal Medicine, 102:169-175, 1985.
Honors and Awards
Honors for Basic Sciences curriculum (top 10% of class), Hahnemann Medical School B.S. Cum Laude, Departmental Honors (Biology), Ursinus College; Sigma Xi National Research Honor Society; Cub and Key Honor Society, Ursinus College Intern of the Year, Thomas Jefferson University Hospital American Cancer Society Clinical Fellow Fellow of the Leukemia Society of America Special Fellow of the Leukemia Society of America Alumni Award, Ursinus College 2010