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Edward Joseph Fox, M.D.

Professor of Orthopaedics and Rehabilitation and Medicine

Office Location

Penn State Hershey Bone and Joint Institute
30 Hope Drive, Building B, Suite 2400
Hershey, PA 17033-0850
Tel: 800-243-1455 / 717-531-5638 Fax: 717-531-0983


Musculoskeletal Oncology Orthopaedic Surgery

Patient Services Provided

Musculoskeletal tumors Limb salvage surgery Benign/malignant bone tumor Metastatic cancer Benign/malignant soft tissue tumors Osteoporosis/metabolic bone diseases

Professional Education

Fellowship, Musculoskeletal Oncology Surgery, Massachusetts General Hospital-Harvard Medical School (2001) Residency, Orthopaedic Surgery, SUNY at Stony Brook, College of Medicine (2000) Residency, Surgery, General, SUNY at Stony Brook, College of Medicine (1996) M.D., University of Rochester, School of Medicine & Dentistry (1995)

Research Interests

My clinical specialty of Musculoskeletal Oncology Surgery has lead me to perform bench top basic science and clinical research of both benign and malignant tumors of the bone and soft tissue, with an emphasis on sarcomas.

My current clinical research is in the area of osteoporosis.  We hope that this work will foster not only further understanding of treatment gaps in osteoporosis care, but also ameliorating that treatment gap as well.  I am co-investigator with Dr. Sciamanna of a PCORI grant that was recently awarded early 2015 studying the effects of Integrating Patient-Centered Exercise Coaching into Primary Care to Reduce Fragility Fracture.

Academic Interests

My academic interests range from teaching medical students and residents to the organization of multidisciplinary clinical tumor teams to foster better patient care and research.

I am currently Director of Medical Student Musculoskeletal Education within the Dept. Orthopaedic Surgery and also Co-Director of several musculoskeletal medical student courses, ranging from musculoskeletal examination to musculoskeletal oncology and metabolic bone diseases.  In addition I also lecture to our residents in Orthopaedic Surgery as well as other departments such as Adult and Pediatric Hematology Oncology, General Surgery, and Radiology.

I have formed a multidisciplinary Sarcoma Board, the main goal of which is to discuss and coordinate sarcoma patient care from a multidisciplinary approach amongst other specialty providers such as Hematology/Oncology, Radiation Oncology, Neurosurgery, Surgical Oncology, Musculoskeletal Radiology, and Musculoskeletal Pathology; this also fosters research efforts and collaborations.

This multidisciplinary effort has led way to a very unique to Pennsylvania Skin and Connective Tissue Oncology Clinic which allows the newly diagnosed cancer patient access to a team approach to their cancer care; i.e. coordinated clinic visits and testing cuts down on additional travel and time spent at the hospital while also providing the patient with more rapid diagnosis and treatment plan.


Rosier RN, Hicks DG, Fox EJ, O'Keefe, R. et al.
Constitutive Expression of P-Glycoprotein in Chondrosarcoma May Explain Chemotherapeutic Resistance
Fox EJ, Hau MA, Gebhardt MC, Hornicek FJ, et al.
Long-Term Followup of Proximal Femoral Allografts Apr 2002
Fox EJ, Torbert JT, Martin AM, Staddon AP, et al.
The Effects of Ciprofloxacin and Paclitaxel on Metastatic and Recurrent Human Chondrosarcoma.
Gamble K, Dardarian TS, Finstein J, Fox EJ, et al.
Osteomyelitis of the Pubic Symposium in Pregnancy
Nikkel LE, Hollenbeak CS, Fox EJ, Uemura T, Ghahramani N
Risk of Fractures After Renal Transplantation in the United States Jun 2009

Honors and Awards

AOA membership