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Nelson Shu-Sang Yee, M.D., Ph.D., R.Ph.

Office Information

Penn State Hershey Cancer Institute
500 University Drive
Hershey, PA 17033
Tel: 800-243-1455 / 717-531-6585 Fax: 717-531-0429



Patient Services Provided

Pancreatic Cancer Hepatocellular Carcinoma Biliary Tract Cancer Esophageal Cancer Gastric Cancer Other Malignancies of Digestive Organs

Practice Locations

Professional Education

Fellowship, Hematology/Oncology, Hospital of the University of Pennsylvania (2001) Residency, Internal Medicine, Hospital of the University of Pennsylvania (1998) Internship, Internal Medicine, Hospital of the University of Pennsylvania (1996) M.D., Cornell University Medical College (New York) (1995)

Research Interests

Clinical Trials of Cancer Therapy in Digestive Organs
Clinical Evaluation of Cancer Biomarkers in Digestive Organs
Pancreatic Cancer: Pathogenesis, Biomarkers, and Targets
Pancreatic Development

Academic Interests

Regional Editor, Clinical Cancer Drugs
Guest Editor, Current Clinical Pharmacology
Host Editor, Frontiers in Oncology
Director, Clinical Elective in Medical Oncology, Penn State College of Medicine
Director, Acting Internship in Medical Oncology, Penn State College of Medicine
Director, Medicine Clerkship in Medical Oncology, Penn State College of Medicine


Yee NS, Kazi AA, Yee RK
Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics.

Zebrafish 2013; 10: 132-146.

Yee NS
Toward the goal of personalized therapy in pancreatic cancer by targeting the molecular phenotype.
Advances in Experimental Medicine and Biology 2013; 779: 91-143.
Yee NS, Zhou W, Lee M, Yee RK
Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma
Cancer Letters 2012; 318:99-105
Yee NS, Zhou W, Chun SC, Liang I-C, Yee RK
Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer
Biology Open 2012; 1:295-307
Yee NS, Zhou W, Liang I-C
Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer
Disease Models & Mechanisms 2011; 4: 240-254
Show all publications »

Honors and Awards

Doctor of Philosophy (Molecular Biology), Cornell University and Memorial Sloan-Kettering Cancer Center Dual B.S. (Pharmacy and Chemistry), Summa Cum Laude, Valedictorian, Massachusetts College of Pharmacy Medical Scientist Training Program Fellowship, Robert Wood Johnson, Jr. Charitable Trust American Cancer Society Alvan T. and Viola D. Fuller Jr. Research Fellowship, Dana-Farber Cancer Institute American Cancer Society Junior Faculty Seed Grant Award, University of Iowa Eli Lilly Achievement Award Rho Chi, The Academic Honor Society in Pharmacy The William Osler Society of Fellows in Medicine, University of Pennsylvania Mentored Clinical Scientist Development Award, National Institutes of Health