No photo available.

Jeffrey M. Sundstrom, M.D., Ph.D.

Bennet and Inez Chotiner Early Career Assistant Professor of Ophthalmology, Neural & Behavioral Sciences, and Cellular & Molecular Physiology

Office Information

Penn State Hershey Eye Center
100 Campus Drive, Entrance 1, Suite 800
Hershey, PA 17033
Tel: 800-243-1455 / 717-531-5690 Fax: 717-531-5009



Patient Services Provided

Diabetic Retinopathy Medical Retina Eye care

Practice Locations

Biographical Information

Board Certified, American Board of Ophthalmology

Professional Education

Fellowship, Medical Retina, University of Michigan Medical School (Ann Arbor) (2013) Residency, Ophthalmology, Milton S. Hershey Medical Center (2012) Internship, Medicine, Milton S. Hershey Medical Center (2009) M.D., Penn State Hershey College of Medicine (2008)

Research Interests

Dr. Sundstrom’s research program focuses on the development of biomarkers and novel therapeutic targets for age-related macular degeneration (AMD), the leading cause of legal blindness in the United States.  In 2006, intravitreal injection of anti-VEGF antibodies were shown to improve vision in patients with neovascular AMD.  Although this intervention has revolutionized the treatment of AMD, less than half of the patients respond with modest improvements visual acuity and no treatment exists for non-exudative AMD.  Dr. Sundstrom has developed a deep proteomics assay capable of identifying retinal derived proteins from clinical vitreous samples.    Comparative vitreous proteomic studies are ongoing in an effort to identify proteins associated with end-stage neovascular and non-exudative AMD.  Preclinical research will subsequently be conducted to validate these newly identified biomarkers and/or therapeutic targets.  Dr. Sundstrom’s educational responsibilities include mentoring medical students for the Medical Student Research project as well as teaching Ophthalmology residents both in the clinic and through a monthly Retina Imaging Conference.


Simo R, Sundstrom JM, Antonetti DA.
Ocular anti-vascular endothelial growth factor (VEGF) therapy for diabetic retinopathy: the role of VEGF in the pathogenesis of diabetic retinopathy.
Demirci H, Cullen A, Sundstrom JM
Enhanced Depth Imaging Optical Coherence Tomography Characteristics of Choroidal Metastasis.
Titchenell PM, Felinski E, Lin CM, Sundstrom JM, Smith CD, Antonetti DA
Atypical PKC Inhibitors Block VEGF-Induced Retinal Permeability.
Ely A, Evans J, Sundstrom JM, Malysz J, Specht C, Wilkinson M
Orbital involvement in extranodal natural killer T cell lymphoma: An atypical case presentation and review of the literature.
Tash BR, Bewley M, Russo M, Keil J, Sundstrom JM, Antonetti DA, Flanagan JM
SAXS and NMR cross saturation define the interface between occludin and ZO-1: Implications for modulating tight junction complex formation.
Show all publications »

Honors and Awards

Heed Fellowship, 2012 American Ophthalmological Society Travel Grant, 2013