Bioengineering - Cardiovascular Biomaterials Lab

This laboratory is under the direction of Dr. Christopher Siedlecki and is part of the Biomedical Engineering Institute, a joint endeavor between the Department of Surgery at the Penn State Milton S. Hershey Medical Center and the Department of Bioengineering at the Pennsylvania State University. The research efforts in the laboratory are focused towards understanding the molecular mechanisms responsible for thrombogenesis on implanted cardiovascular biomaterials. The relationships between the implanted biomaterial, the circulating plasma proteins, and the cellular elements of blood are poorly understood, particularly at the molecular and submolecular levels. We utilize a variety of sensitive analytical and experimental techniques, novel nano- and microfabrication methodologies and mathematical modeling to elucidate these interactions in order to define parameters for the rational development of new biomaterials.