Drug Discovery, Development and Delivery Core
Director: Kent Vrana, Ph.D.
Phone: 717-531-8285
Email: kev10@psu.edu
Lab Manager: Adam Beck, M.S.
Phone: 717-531-0003 x285094
Email: ajb40@psu.edu
Research Technician: Jennifer Fritz
Phone: 717-531-0003 ext 28-5888
Email: jxf37@psu.edu
The Drug Discovery, Development and Delivery Core provides investigators with access to technological expertise enabling RNAi and compound library screening.
Services provided by the Core
- Drug Screening
- siRNA Screening
- Other information
Location
The Drug Discovery, Development and Discovery Core is located in the Department of Pharmacology in the Hershey Center for Applied Research Building Room 3400. (www.hersheyresearch.com)
Synergy Analysis
The Core now has available BioSoft's Calusyn software. This software allows one to determine whether two drugs act synergistically or not. For new users, the Core provides a training session that covers experimental design, data entry and analysis of results ($11.78). After training, investigators may arrange to do their own analysis ($3 per combination) or have the Core perform the analysis ($10.77). We also have the capability to run your synergy assay. Contact us to discuss pricing.
Transfection Optimization
The Core now provides transfection optimization using RNAiMax Lipofectamine. This includes transfection reagents, scrambled siRNA and All Stars Cell Death control as a positive control. Investigators may provide other positive controls related to their assay .
Assay Development
- Invitrogen: Target & Lead Identification & Validation
- Qiagen:Cignal 45-Pathway Reporter Array
- Echelon: Lipid Assays
- zenbio: Primary Human Cells
- Active Motif: ELISAs
Chemical Library information
- Collaborative Drug Discovery
- PubChem: On-line chemical search engine
- Qiagen: ALLSTARs Cell Death control
- TimTec: Natural Product Library
- Chembridge: DIVERset Chemical Library
siRNA information