Mechanisms of Carcinogenesis
Program Leaders: K. Sandeep Prabhu, PhD and Clare Sample, PhD
The overall goal of the MC Program is to investigate the mechanisms of carcinogenesis induced by viruses, chemicals, and environmental/dietary agents through basic research. Novel carcinogenic mechanisms identified by the MC Program will be applied towards the prevention and treatment of human cancers in collaboration with the PHCC Program and the ET Program, respectively.
Aim 1: To examine the mechanisms of oncogenic viral infections, replication, structural assembly and maturation, and pathogenesis in carcinogenesis.
Aim 2: To elucidate the mechanisms of environmental-induced carcinogenesis and the impact of genetic/dietary/environmental interactions on cancer susceptibility.
Aim 3: To identify immunological targets that influence the multi-step carcinogenesis process.