Acute Care

Cure Asthma Study - A Pilot Study of Personalized Medicine for Pediatric Asthma (IRB# 38403)

Status: Active



  • Principal Investigator: Adam Spanier, MD, PhD, MPH



Asthma is one of the most common, chronic diseases of childhood affecting approximately ten percent of US children and adolescents.  Asthma is a complex disease without a uniform presentation, and asthma triggers, treatment responsiveness, and severity vary by individual.  This varied disease manifestation can be a challenge for clinicians managing asthma. 
The presence of genetic differences which can affect response to treatment suggests that an individualized therapeutic plan may be more appropriate than the  relatively uniform, standardized approach found in the current NAEPP guidelines. 
Besides the genetic differences in medication response, social and environmental factors have been identified which play a role in the exacerbation of asthma.




Inclusion criteria include: 1) child age 6-17 years, 2) doctor diagnosed asthma, 3) at least one asthma exacerbation in the previous year.  Children with other coexistent pulmonary diseases such as chronic lung disease and cystic fibrosis will be excluded.
Asthma can develop at any age, but in most patients asthma presents before puberty.  The diagnosis of asthma is often delayed until a child is older so that it can be determined that a child has disease that is not going to be, "outgrown."  It is imperative that studies of childhood asthma involve children beyond the first few years of life in order to avoid disease misclassification.  We will enroll children who are six years of age and older because epidemiologic studies have demonstrated that patterns of wheezing consistent with persistent asthma are usually established by six years of age and do not appear to change significantly afterward. 



Additional Study Details:

We will recruit participants from the Hershey Pediatric Clinic at Hope Drive via physician or nurse referral.  Parents of children who may be eligible will contact study staff to obtain more information and to be have a phone screening for enrollment criteria. 




Penn State Milton S. Hershey Medical Center
Pediatrics at 35 Hope Drive



Pediatric Clinical Research Office




  • Acute Care