Publications

  1. Harris LRH, Poritz LS. Alteration of occludin expression in intestinal inflammation. Inflamm Bowel Dis, 2011. In press.
  2. Harris LRH, Poritz LS. Increase in the tight junction protein claudin-1 in intestinal Inflammation. Dig Dis Sci 2011 in press.
  3. Harris LRH, Poritz LS. NOD2 mutation disrupts the tight junction complex in ileal epithelial cells. J Cell Physiol. 2011. In press.
  4. Haveran LA, Sehgal R, Poritz LS, McKenna KJ, Stewart DB, Koltun WA. Infliximab and/or azathioprine in the treatment of Crohn's disease-like complications after IPAA. Dis Colon Rectum. 2011 Jan;54(1):15-20.
  5. Sehgal R, Berg A, Figueroa R, Poritz LS, McKenna KJ, Stewart DB, Koltun WA..Risk factors for surgical site infections after colorectal resection in diabetic patients. 2011 J Am Coll Surg. Jan;212(1):29-34
  6. John G, Hegarty JP, Yu W, Berg A, Pastor DM, Kelly AA, Wang Y, Poritz LS, Schreiber S, Koltun WA, Lin A. NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT. Mol Genet Metab 2011 in press.
  7. Lin Z, Hegarty J, Cappel J, Yu W, Chen X, Faber P, Wang Y, Kelly A, Poritz L, Peterson B, Schreiber S, Fan JB, Koltun W. Identification of disease-associated DNA methylation in intestinal tissues from patients with inflammatory bowel disease. Clin Genet. 2011 Jul;80(1):59-67.
  8. Lin Z, Hegarty JP, Berg A, Wang Z, Kelly AA, Wang Y, Poritz LS, Wu R, Koltun WA. DLG5 P1371Q: Genetic association with inflammatory bowel disease and allelic complementation to R30Q in disease susceptibility. Swiss Med Wkly 2011. in press.
  9. Lin Z, Hegarty JP, Lin T, Ostrov B, Wang Y, Yu W, Kelly AA, Poritz LS, Koltun WA. Failure of anakinra treatment of pyoderma gangrenosum in an IBD patient and relevance to the PSTPIP1 gene. Inflamm Bowel Dis. 2011 Jun;17(6):41-2.
  10. Lin Z, John G, Hegarty, Berg A, Yu W, Wang Y, Kelly AA, Peterson BZ, Poritz LS, Floros J, Koltun WA. Genetic variants and differential allele expression of surfactant protein D in inflammatory bowel disease. Ann Hum Genet 2011. in press.
  11. Lin Z, Nelson L, Franke A, Poritz L, Li TY, Wu R, Wang Y, MacNeill C, Thomas NJ, Schreiber S, Koltun WA. OCTN1 variant L503F is associated with familial and sporadic inflammatory bowel disease. J Crohns Colitis. 2010 Jun;4(2):132-8. Epub 2009 Oct 24.
  12. Lin Z, Poritz L, Franke A, Li TY, Ruether A, Byrnes KA, Wang Y, Gebhard AW, MacNeill C, Thomas NJ, Wu R, Schreiber S, Koltun WA. Genetic association of DLG5 R30Q with familial and sporadic inflammatory bowel disease in men. Dis Markers. 2009;27(5):193-201.
  13. Lin Z, Poritz L, Franke A, Li TY, Ruether A, Byrnes KA, Wang Y, Gebhard AW, MacNeill C, Thomas NJ, Schreiber S, Koltun WA. Genetic association of nonsynonymous variants of the IL23R with familial and sporadic inflammatory bowel disease in women. Dig Dis Sci. 2010 Mar;55(3):739-46. Epub 2009 Mar 18.
  14. Poritz LS, Garver KI, Green C, Fitzpatrick L, Ruggiero F, Koltun WA. Loss of the tight junction protein ZO-1 in dextran sulfate sodium induced colitis. J Surg Res. 2007 Jun 1;140(1):12-9. Epub 2007 Apr 6.
  15. Poritz LS, Garver KI, Tilberg AF, Koltun WA. Tumor necrosis factor alpha disrupts tight junction assembly. J Surg Res. 2004 Jan;116(1):14-8.
  16. Sehgal R, Berg A, Hegarty JP, Kelly AA, Lin A, Poritz LS, Koltun WA. Gene signature modeling to predict risk of Crohn's disease (CD) like complications or severe pouchitis (SP) after ileal pouch anastomosis (IPAA). Dis Colon Rectum. 2011. In press.
  17. Sehgal R, Berg A, Hegarty JP, Kelly AA, Lin Z, Poritz LS, Koltun WA. Mutations in IRGM are associated with more frequent need for surgery in ileocolonic Crohn's disease. Dis Colon Rectum. 2011, in press.
  18. Sehgal R, Berg A, Hegarty JP, Kelly AA, Lin Z, Poritz LS, Koltun WA. NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis. Dis Colon Rectum. 2010 Nov;53(11):1487-94.
  19. Sehgal R, Hegarty JP, Berg A, Pastor DM, Kelly AA, Poritz LS, Lin Z, Vrana KE, Koltun WA. Changes in serum protein levels in ulcerative colitis patients following proctocolectomy. Surgery. 2011. In press.
  20. Sehgal R, Koltun WA. Scoring systems in inflammatory bowel disease. Expert Rev Gastroenterol Hepatol. 2010 Aug;4(4):513-21.
  21. Wang Z, Liu T, Lin Z, Hegarty J, Koltun WA, Wu R. A general model for multilocus epistatic interactions in case-control studies. PLoS One. 2010 Aug 18;5(8):e11384.
  22. Wisner DM, Harris LR 3rd, Green CL, Poritz LS. Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4. J Surg Res. 2008 Jan;144(1):1-7. Epub 2007 Jul 19.
  23. Yu W, Hegarty JP, Berg A, Chen X, West G, Kelly AA, Wang Y, Poritz LS, Koltun WA, Lin Z. Nkx2-3 transcriptional regulation of Endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells. PLoS One. 2011;6(5):e20454.
  24. Yu W, Lin Z, Chen X, Hegarty JP, Kelly AA, Wang Y, Poritz LS, Koltun WA. Genes differentially regulated by Nkx2-3 in B cells between ulcerative colitis and Crohn's disease patients: Implication of EGR1. Dig Dis Sci 2011. In press.
  25. Yu W, Lin Z, Hegarty JP, John G, Chen X, Faber PW, Kelly AA, Wang Y, Poritz LS, Schreiber S, Koltun WA. Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: implication of endothelin-1 in inflammatory bowel disease. Mol Genet Metab. 2010 May;100(1):88-95.
  26. Yu W, Lin Z, Kelly AA, Hegarty JP, Poritz LS, Wang Y, Li T, Schreiber S, Koltun WA. Association of a Nkx2-3 polymorphism with Crohn's disease and expression of Nkx2-3 is up-regulated in B cell lines and intestinal tissues with Crohn's disease. J Crohns Colitis. 2009 Sep;3(3):189-95.
  27. Yu W, Lin Z, Pastor DM, Hegarty JP, Chen X, Kelly AA, Wang Y, Poritz LS, Koltun WA. Genes regulated by Nkx2-3 in sporadic and inflammatory bowel disease-associated colorectal cancer cell lines. Dig Dis Sci. 2010 Nov;55(11):3171-80.
  28. Yu W. Hegarty JP, Berg A, Kelly AA, Wang Y, Poritz LS, Franke A, Schreiber S, Koltun WA, Lin Z. PTPN2 is associated with Crohn's disease and its up-regulation in CD patients mediated by Nkx2-3. Dis Markers 2011. in press.