Student Directory

Darrin Bann

Class Year: M4

 

Department/Institute/Center(s):

  • M.D./Ph.D. Program

 

Contact Information:

 

Biographical Information:

Hometown: South Orange, NJ

 

Education:

Undergraduate Education:  BA/06 Biology/Ithaca College, NY

 

Research Interests:

Research Interest: Understanding cellular regulation of retrovirus and retrotransposon replication

Advisor: Leslie Parent, MD
Graduate Program: Cell & Molecular Biology

Thesis: (tba)

Description: Retroelements, including retroviruses and retrotransposons, replicate through an RNA intermediate and integrate into the host genome.  These integrations cause mutations that lead to cancer by disrupting cellular gene expression or damaging DNA.  As a result, cellular defense pathways have evolved to limit retroelement replication.  The overall goal of my work is to understand how retroviruses and retrotransposons overcome or evade these cellular defenses.  Using the oncogenic retrovirus mouse mammary tumor virus (MMTV) as a model system, we have found that cellular messenger RNA processing factors may constitute part of a defense pathway aimed at restricting retroelement replication.  However, MMTV and other retroelements appear to hijack this cellular defense pathway to facilitate their own replication.

Meeting Presentations

  • 2010
    Penn State College of Medicine Graduate Research Forum, Hershey, PA
    15th Annual Meeting of the RNA Society, University of Washington, Seattle, WA
    Cellular & Molecular Biology Research Day, Penn State College of Medicine, Hershey, PA
    11th Annual Symposium on Antiviral Drug resistance, Hotel Hershey, Hershey, PA
  •  2011
    Penn State College of Medicine Graduate Research Forum, Hershey, PA
    Cold Spring Harbor Laboratory Meeting on Retroviruses, Cold Spring Harbor, NY
    12th Annual Symposium on Antiviral Drug Resistance, Hotel Hershey, PA 
  • 2012
    Penn State College of Medicine Graduate Research Forum, Hershey, PA (oral)
    Cold Spring Harbor Laboratory Meeting on Retroviruses, Cold Spring Harbor, NY (oral)
    National MD/PhD Student Conference, Keystone, CO (poster)


 

 

 

Publications:

Condon M, Adams DC, Bann D, Flaherty K, Gammons J, Johnson J, Lewis ML, Marsteller S, Scheffer SJ, Serna F, and Swensen S. (2008) Uncovering tropical diversity: six sympatric cryptic species of Blepharoneura (Diptera: Tephritidae) in flowers of Gurania spinulosa (Cucurbitaceae) in eastern Ecuador  Biol. J. Linnean Soc 93: 779-797

Bann DV, Parent LJ (2012) Application of Live-Cell RNA Imaging Techniques to the Study of Retroviral RNA Trafficking Viruses 4(6):963-979 PMID: 22816035

Lochman TL, Bann DV, Ryan EP, Beyer AR, Mao A, Cochrane A, Parent LJ (2013) NC-mediated nucleolar localization of retroviral Gag proteins Virus Res 171(2):304-18 PMID: 23036987

Bann DV*, Beyer AR*, Rice B, Pultz IS, Kane M, Goff SP, Golovkina TV, Parent LJ (2012) Nucleolar Trafficking of the Mouse Mammary Tumor Virus Gag Protein Induced by Interaction with Ribosomal Protein L9 J Virol 87(2):1069-82 PMID: 23135726 *authors contributed equally

Nadaraia-Hoke S*, Bann DV*, Lochmann TL, Gudleski-O'Regan N, Parent LJ (2013) Alterations in the MA and NC domains modulate phosphoinositide-dependent plasma membrane localization of the Rous sarcoma virus Gag protein J Virol 87(6):3609-15 PMID: 23325682 *authors contributed equally

Stake MS, Bann DV, Kaddis RJ, Parent LJ (2013) Nuclear trafficking of retroviral RNAs and Gag proteins during late steps of replication Viruses 18;5(11):2767-95 PMID:  24253283

Bann DV, Goyal N, Goldenberg D (2014) Papillary thyroid cancer in a gravid woman ENT J (accepted)

Bann DV, Goyal N, Goldenberg D (2014) Parathyroid adenoma in a woman with secondary hyperparathyroidism ENT J (accepted)

Bann DV, Beyer AR, Parent LJ (2014) A murine retrovirus co-opts YB-1, a translational regulator and stress granule-associated protein, to facilitate virus assembly J Virol (accepted)

Bann DV, Goyal N, Camacho F, Goldenberg D (2014) Rise in incidence rates of thyroid cancer in the Commonwealth of Pennsylvania  JAMA Otolaryngology - Head & Neck Surgery (accepted)

 

 

 

Darrin Bann

 

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