Class Year: LOA
Undergraduate Education: BS/08 Physiology;Psychology/Michigan State U
Advisor: James Connor, PhD
Graduate Program: Neuroscience
Thesis: "Understanding the role of HFE Polymorphism in Cancer"
Research Interest: The relationship between iron metabolism and cancer progression
Description: To better understand cancer biology and the interplay between tumor progression and iron, I am making use of a variety of in vitro and in vivo models. In brief, I am studying the effects of iron loading, iron chelation, HFE (a protein involved in iron handling that is commonly mutated in the population) status, and H-ferritin deficiency. My outcomes of interest include whole-animal metastatic spread (assessed using IVIS luciferase imaging), cell viability and DNA turnover in culture, and chemotherapeutic sensitivity.
Michigan State University Undergraduate Research & Arts Forum, MI
International BioIron Society, London, UK
Weston CL, Glantz MJ, Connor JR (2011) Detection of cancer cells in the cerebrospinal fluid: current methods and future directions Fluids Barriers CNS 8(1):14 PMCID: PMC3059292
Zalatimo O, Zoccoli CM, Patel A, Weston CL, Glantz M (2013) Impact of genetic targets on primary brain tumor therapy: what's ready for prime time? Adv Exp Med Biol 779:267-89 PMCID: (no number)
Weston C, Connor JR (2014) Evidence for the influence of the iron regulatory MHC class I molecule HFE on tumor progression in experimental models and clinical populations Translational Oncogenomics (accepted)
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