Class Year: M4
- M.D./Ph.D. Program
- Email: firstname.lastname@example.org
Hometown: Harrisburg, PA
Undergraduate Education: BS/03 Human Biology/Brown U, RI
Research Interest: The goal of my research projects is to understand interactions between hosts and pathogens during bacterial colonization of the upper respiratory tract.
Advisor: Eric Harvill, PhD
Graduate Program: IBIOS/Immunobiology
Thesis: How Host and Pathogen Adaptations Influence the Transmission of Bordetella bronchiseptica
Description: Small doses of aerosolized bacteria are frequently inhaled by animal hosts, yet most microbes will rarely colonize and establish residence. Once inside the host, the ability of a bacterium to populate is obstructed by numerous host defenses as well as other microbes already residing there. If a bacterium is to succeed at colonizing a new host, it must be equipped with the means to evade, endure or disarm the forces resisting its presence.
Weyrich LS, Rolin OY, Muse SJ, Park J, Spidale N, Kennett MJ, Hester SE, Chen C, Dudley EG, Harvill ET (2012) A Type VI Secretion System Encoding Locus is Required for Bordetella bronchiseptica Immunomodulation and Persistence In Vivo PLoS One 7(10):e45892
Rolin O, Muse S, Safi C, Elahi S, Gerdts V, Hittle L, Ernst R, Harvill E, Preston A (2013) Enzymatic Modification of the Lipid A by an ArnT Protects B. bronchiseptica Against Cationic Peptides and is Required for Transmission Infection & Immunity (accepted)
Weyrich1,2 L, Feaga1,2 H, Park1,4 J, Muse1,2 S, Safi1 C, Rolin1,3 O, Young1 S, Harvill1 E (2013) Resident Microbiota Affect Bordetella pertussis Infectious Dose and Host Specificity (Running Title: Host Microbiota inhibit B. pertussis colonization) J of Infectious Disease (accepted)
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