Student Directory

Xiaowei (Bill) Su

Class Year: M3

 

Department/Institute/Center(s):

  • M.D./PhD. Program

 

Contact Information:

 

Biographical Information:

Hometown: Cheshire, CT

 

Education:

Undergraduate Education:  BS/08 Biology/Yale

 

Research Interests:

Research Interest: The effect of H63D HFE polymorphism on mitochondrial dysfunction in amyotrophic lateral sclerosis

Advisor: James Connor, PhD
Graduate Program: Molecular Medicine

Thesis:

Description:Amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease), is a debilitating neurodegenerative disorder affecting both upper and lower motor neurons.  Research from our lab and others has shown that approximately 30% of ALS patients with the sporadic form of ALS carry a mutation in the HFE gene, which is associated with iron overload in hemochromatosis.  Furthermore, ongoing studies suggest a role for mitochondrial dysfunction in the pathogenesis of ALS.  Changes in mitochondrial morphology, localization, calcium buffering capacity, and regulation of oxidative phosphorylation as well as mitophagy and apoptosis occur in mouse models of the disease.  Building upon these findings, my research will investigate the role of mitochondrial dysfunction in various model systems relevant to ALS.  I will study human cell lines carrying mutant HFE vectors, as well as mice with HFE, superoxide dismutase (SOD, implicated in familial ALS) or both HFE and SOD gene mutations.  Finally, I will build upon current lab collaborations with the Penn State Hershey ALS Clinic to analyze mitochondrial dysfunction as well as biomarkers correlated with clinically meaningful prognostic indicators in patients.

Meeting Presentations
  • 2008
    Society for Neuroscience, Washington, D.C. (poster)
  • 2009
    Society for Neuroscience, Chicago, IL (poster)
  • 2010
    6th International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion (5 posters;1 slide presentation)
    Pediatric Research Day, PSHMC, Hershey, PA (slide presentation)
  • 2012
    International Symposium on Amyotrophic Lateral Sclerosis and Motor Neuron Disease, Chicago, IL (1 oral presentation, 1 poster)
  • 2013
    International BioIron Society, London, England (1 poster)
    Society for Neuroscience 2013, San Diego, CA (2 posters)
    International Symposium on Amyotrophic Lateral Sclerosis and Motor Neuron Disease, Milan, Italy (1 poster)

 

Publications:

Su XW, Li XY, Banasr M, Koo JW, Shahid M, Henry B, Duman RS (2009) Chronic Treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus Psychopharmacology 206(2):215-22 PMID: 19603152  PMCID:  (no number)

Su XW, Li XY, Banasr M, Duman RS (2009) Eszopiclone and fluoxetine enhance the survival of newborn neurons in the adult rat hippocampus Int J of Neuropsychopharmacology 12(10):1421-8 PMID: 19775501  PMCID:  PMC3677220

Su XW and ‹ndar A (2009) Brain Protection During Pediatric Cardiopulmonary Bypass Artificial Organs 34(4):E91-E102 PMID: 20420605   PMCID:  (no number)

Guan Y, Su XW, McCoach R, Kunselman A, El-Banayosy A, ‹ndar A (2009) Mechanical performance comparison between RotaFlow and CentriMag centrifugal blood pumps in an adult ECLS model Perfusion 25(2):71-6 PMID: 20212070  PMCID:  (no number)

Guan Y, Su XW, McCoach R, Wise R, Kunselman A, ‹ndar A (2009) Evaluation of Quadrox-i ® Adult Hollow Fiber Oxygenator with Integrated Arterial Filter J of Extracorporeal Technology 42(2):134-8 PMID: 20648898  PMCID:  (no number)

Girgenti MJ, Collier E, Sathyanesan M, Su XW, Newton SS (2010) Characterization of electroconvulsive seizure-induced TIMP-1 and MMP-9 in hippocampal vasculature Int J of Neuropsychopharmacology 1-10; 14(4): 535-44 PMID: 20678305  PMCID:  (no number)

Yee S, Qiu F, Su XW, Rider A, Kunselman AR, Guan Y, Undar A (2010) Evaluation of HL-20 Roller Pump and Rotaflow Centrifugal Pump on Perfusion Quality and Gaseous Microemboli Delivery Artif Organs doi: 10.1111/j.1525-1594; 34(11): 937-43  PMID: 20946282  PMCID:  (no number)

Qiu F, Guan Y, Su X, Kunselman A, Undar A (2010) Evaluation of Neonatal Membrane Oxygenators with Respect to Gaseous Microemboli Capture and Transmembrane Pressure Gradients Artif Organs 34(11):923-929 PMID: 21092035  PMCID:  (no number)

Su XW, Qui F, Undar A (2011) Brain Protection During Pediatric CPB Chin J ECC 9(1): 40-47  PMCID:  (no number)

Su XW, Guan Y, Barnes M, Clark JB, Myers JL, Undar A (2011) Improved cerebral oxygen saturation and blood flow pulsatility with pulsatile perfusion during pediatric cardiopulmonary bypass  Ped Res 70(2):181-85  PMCID:  (no number)

Su XW, Lee SY, Mitchell RM, Stephens HE, Simmons Z, Connor JR (2013) H63D HFE polymorphisms are associated with decreased SOD1 expression in the muscle of amyotrophic lateral sclerosis patients J Muscle and Nerve 48(2):242-6 PMID 23813494  PMCID:  (no number)

Su XW, Simmons Z, Mitchell RM, Kong L, Stephens HE, Connor JR (2013) Biomarker-based predictive models for prognosis in amyotrophic lateral sclerosis JAMA Neurology 70(12):1505-11 PMID:  24145899  PMCID:  (no number)

Su XW, Broach JR, Connor JR, Gerhard GS, Simmons Z (2014) Genetic heterogeneity of ALS:  implications for clinical practice and research  Muscle and Nerve 49(6):786-803  PMCID:  (no number)

 

 

 

 

Xiaowei (Bill) Su

 

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