Grants

Kevin M. Cockroft, M.D.
Principal Investigator:  Joseph P. Broderick, M.D, University of Cincinnati Neuroscience Institute
Primary Institute:  University of Cincinnati
Role:  Site Principal Investigator
Co-Investigators:  Raymond K. Reichwein, M.D., David C. Good, M.D., Paul Kalapos, M.D., Kerstin Bettermann, M.D., Department of Neurology
Title:  "Interventional Management of Stroke Trial III (IMS III)"
Funding Agency:  National Institutes of Health (5 U01 NS052220-07)
Period:  09/30/2011-07/31/2015
Amount:  $101,836

Principal Investigator:  Daniel F. Hanley, M.D., Department of Neurology
Primary Site:  The Johns Hopkins University
Role:  Site Principal Investigator
Title:  "CLEAR III: Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage"
Funding Agency:  National Institutes of Health (5 U01 NS-062851-04)
Period:  07/01/2009-06/30/2014
Amount:  $355,253
 

James R. Connor, Ph.D.
Co-Investigator:  Hamid A. Al-Mondhiry, M.D., Department of Hematology/Oncology
Title:  "Trial to Evaluate the Safety and Tolerability of a Novel Oral Iron Supplement for the Treatment of Iron Deficiency Anemia"
Funding Agency:  Pennsylvania Tobacco Settlement Fund (TSF)
Period:  01/05/2011-12/31/2013
Amount:  $112,113

Principal Investigator:  Betsy Lozoff, M.D., Department of Pediatrics
Primary Site:  The Regents of the University of Michigan
Role:  Site Principal Investigator
Title:  "Brain and Behavior in Early Iron Deficiency" (Analytical Core)
Funding Agency:  National Institutes of Health (5 P01 HD039386-10)
Period:  08/01/2011-07/31/2013
Amount:  $274,384

Co-Investigator:  A.B. Madhankumar, Ph.D.
Title:  "Apo-ferritin as a Therapeutic Treatment for Amyotrophic Lateral Sclerosis"
Funding Agency:  U.S. Army Medical Research and Development Command
Period:  09/01/2011-09/30/2013
Amount:  $600,304

Principal Investigator:  Todd M. Hulgan, M.D., Department of Medicine
Primary Site:  Vanderbilt University Medical Center
Role:  Site Principal Investigator
Co-Investigator:  Stephanie M. Patton, Ph.D.
Title:  "Iron and Mitochondrial Genomics in Neuroinflammation and HAND:  A Charter Study"
Funding Agency:  National Institutes of Health (5 R01 MH0957621-02)
Period:  05/01/2012-04/30/2014
Amount:  $94,256

Multi PI:  Ian A. Simpson, Ph.D., Department of Neural and Behavioral Sciences
Title:  "Mechanisms and Regulation of Brain Iron Uptake"
Funding Agency:  National Institute of Neurological Disorders and Stroke
Period:  07/01/2012-06/30/2013
Amount:  $490,996

Co-Investigator:  A.B. Madhankumar, Ph.D.
Title:  "Development of a Nanotechnology Platform for Delivery of siRNA to Cancer Cells"
Funding Agency:  PA Tobacco Settlement Funds (TSF)
Period:  07/20/2012-12/31/2013
Amount:  $107,100

Principal Investigator:  Xuemei Huang, Department of Neurology
Role:  Co-Investigator
Title:  "Multimodal MRI Markers of Nigrostriatal Pathology in Parkinson's Disease"
Funding Agency:  National Institutes of Diabetes and Digestive and Kidney Diseases (1 U01NS082151-01)
Period:  09/30/2012-09/29/2013
Amount:  $649,506

Co-Investigator:  A.B. Madhankumar, Ph.D.
Title:  "Targeted Delivery of a Potent Anti-Proliferative Metal Chelator to Brain Tumors"
Funding Agency:  PA Tobacco Settlement Funds (TSF)
Period:  07/01/2013-06/30/2015
Amount: $25,000

Principal Investigators:  James R. Connor, Ph.D., Jeremy N. Rich, M.D., Department of Neurology
Primary Site:  The Cleveland Clinic
Role:  Multi-Principal Investigator
Co-Investigator:  A.B. Madhankumar, Ph.D.
Title:  "Glioblastoma Therapy Through Ferritin Targeting"
Funding Agency:  National Cancer Institute (1R01-CA169117-01A1)
Period:  07/01/2013-04/30/2018
Amount:  $246,204


Mark S. Dias, M.D.
Co-Investigators:  Ian M. Paul, M.D., Department of Pediatrics; Christopher S. Hollenbeak, Ph.D., Department of Surgery; Michele L. Shaffer, Ph.D., Public Health Sciences
Title:  "PA Abusive Head Trauma Prevention Program"
Funding Agency:  Centers for Disease Control and Prevention (5 U49 CE001274-05)
Period:  09/30/2011-09/29/2013
Amount:  $492,537

Title:  "Pennsylvania Shaken Baby Syndrome (SBS) Prevention and Awareness Program"
Funding Agency:  Commonwealth of Pennsylvania:  Department of Health
Period:  07/01/2012-06/30/2014
Amount:  $73,940
Supplemental Funds:  $219,335

Co-Investigators:  Douglas G. Armstrong, M.D., Department of Orthopaedics; Mark R. Iantosca, M.D., Department of Neurosurgery; Ross M. Decter, M.D., Division of Urology/Department of Surgery; Stacy M. Stark, M.D., Department of Physical Medicine and Rehabilitation; Kristine L. Fortuna, M.D., Department of Orthopaedics; Cynthia A. Hulse, Coordinator, Spina Bifida Services; Lizabeth M. Kelly, Physical Therapist
Title:  "Penn State Hershey Spina Bifida Clinic Registry Demonstration Project"
Funding Agency:  Centers for Disease Control and Prevention  (5 U01 DD000736-02)
Period:  09/01/2012-08/31/2013
Amount:  $59,288

Principal Investigator:  Melanie A. Comito M.D., Department of Pediatrics
Role:  Co-Investigator
Co-Investigators:  Jennifer W. Baccon, M.D., Ph.D., Department of Pathology; Robert J. Greiner, M.D., Department of Pediatrics; Mark R. Iantosca, M.D., Department of Neurosurgery; John F. Kuttesch, M.D, Department of Pediatrics; Heath Mackley, M.D., Department of Radiology; Arabinda K. Choudhary, M.B.B.S., Department of Radiology; Charles Specht, M.D., Department of Pathology
Title:  "Phase II Trial of Molecularly Determined Treatment of Children and Young Adults with Newly Diagnosed Diffuse Intrinsic Pontine Gliomas"
Funding Agency:  Dana Farber Cancer Institute
Period:  10/15/2012-09/30/2015
Amount:  $20,000


Michael J. Glantz, M.D., Ph.D.
Co-Investigator:  Jonas M. Sheehan, M.D.
Title:  "A Randomized Phase 1/11 Study of ABT-888 in Combination with Temozolomide in Recurrent (Temozolomide Resistant) Glioblastoma RTOG 0929"
Funding Agency:  Radiation Therapy Oncology Group/National Cancer Institute
Period:  06/01/2012-06/30/2014
Amount:  $9,000


Bruce J. Gluckman, Ph.D.
Department of Engineering Science and Mechanics, Department of Neurosurgery
Co-Investigator:  Steven J. Schiff, M.D., Ph.D., Department of Neurosurgery/Department of Engineering Science and Mechanics
Title:  "Perturbative Seizure Prediction and Detection of a Seizure Permissive State"
Funding Agency:  National Institute of Neurological Disorders and Stroke (5 R01 NS0655096-04)
Period:  05/01/2012-04/30/2014
Amount:  $324,705
Supplemental Funds:  $26,549 (05/10/2011-04/30/2012)


Robert E. Harbaugh, M.D.
Principal Investigator: Raghavan Madhavan, M.D., Department of Neurosurgery
Primary Site: University of Iowa
Role:   Co-Investigator
Title:  "Assessment of Intracranial Aneurysm Shape as an Indicator of Rupture Disk"
Funding Agency:  National Institutes of Health (5 R01 HL083475-05)
Period:  08/01/2011-07/31/2013
Amount:  $154,273


Mark R. Iantosca, M.D.
Co-Investigator:  Mark S. Dias, M.D.
Title:  "The Park-Reeves Syringomyelia Registration and Data Use Agreement"
Funding Agency:  Washington University in St. Louis
Period:  08/08/2011-12/31/2013
Amount:  $50,000

Principal Investigator:  Joan T. Richtsmeier, Ph.D., Department of Anthropology, Pennsylvania State University
Role:  Consultant
Title:  "Midface and Upper Airway in Craniosynostosis"
Funding Agency:  National Institute of Dental and Craniofacial Research (1 RO1 DE022988-01)
Period:  08/10/2012-05/31/2017
Amount:  $641,366


Sang Y. Lee, Ph.D.
Co-Investigator:  Arun K. Sharma, Ph.D., Department of Pharmacology
Title:  "Development of Novel Thiobarbituric Acid Analogs for Lung Cancers"
Funding Agency:  Elsa U. Pardee Foundation
Period:  01/01/2013-12/31/2013
Amount:  $125,000

Co-Investigator:  Arun K. Sharma, Ph.D., Department of Pharmacology
Title:  "Development of Novel Thiobarbituric Acid Analogs for Malignant Brain Tumors"
Funding Agency:  National Cancer Institute (1 R21 CA167406-02)
Period:  04/26/2012-03/31/2014
Amount:  $81,530


Mark D. Meadowcroft, Ph.D.
Title:  "Micro-histological Magnetic Resonance Imaging of White Matter Cytoarchitecture and Integrity in Alzheimer's Disease"
Funding Agency:  Charleston Conference on Alzheimer's Disease (CCAD)
Period:  06/01/2013-05/31/2014
Amount:  $50,000


Stephanie M. Patton, Ph.D.
Co-Investigator:  Urs A. Leuenberger, M.D., Penn State Heart and Vascular Institute
Title:  "The Role that the Nitric Oxide Pathway Plays in Regulating Vasodilation of the Legs in the Restless Legs Syndrome Subjects"
Funding Agency:  Restless Legs Syndrome Foundation, Inc.
Period:  10/01/2011-09/30/2013
Amount:  $25,000


Steven J. Schiff, M.D., Ph.D.
Title:  "CRCNS:  Collaborative Research:  Model-Based Control of Spreading Depression"
Funding Agency:  National Institute of Biomedical Imaging and Bioengineering (5 R01 EB014641-03)
Period:  08/01/2012-07/31/2015
Amount:  $191,127

Title:  "Neurocognitive Outcomes and Changes in Brain and CSF Volume After Treatment of Post-Infectious Hydrocephalus in Ugandan Infants by Shunting vs. ETV/CPC"
Funding Agency:  National Institutes of Health (1 R21 TW009612-01A1)
Period:  09/14/2012-09/30/2014
Amount:  $50,679

Co-Investigators:  Andrew Read, Ph.D., Department of Biology; Bruce J. Gluckman, Ph.D., Department of Engineering, Science and Mechanics/Department of Neurosurgery; Patrick Drew, Ph.D., Department of Engineering, Science and Mechanics/Department of Neurosurgery; Jose Antonio Stoute, M.D., Department of Infectious Disease
Title:  "A Murine Model for Preventing Postmalarial Epilepsy"
Funding Agency:  The Brighter Future Award, Citizens United for Research in Epilepsy (CURE)
Period:  09/01/2012-08/31/2014
Amount:  $350,000 (two year award)

Co-Investigators:  Mary Poss, D.V.M., Ph.D., Biology; Vivek Kapur, B.V., Sc., Ph.D., Veterinary and Biomedical Sciences
Title: "Defining the Neonatal Septisome and Post-infectious Hydrocephalus"
Funding Agency:  Pennsylvania Tobacco Settlement Funds
Period:  12/12/12-12/31/13
Amount:  $44,800


Philip A. Villanueva, M.D.
Principal Investigator: Barbara A. Gregson, Ph.D., The Institute of Neuroscience
Primary Site:  New Castle General Hospital - United Kingdom
Role:  Site Principal Investigator
Co-Investigators:  James McInerney, M.D., G. Timothy Reiter, M.D., Michael D. Sather, M.D.
Title:  "Surgical Trial in Traumatic Intracerebral Haemorrhage"
Funding Agency:  National Institutes of Health
Period:  02/14/2011-02/29/2016
Amount:  $58,661


J. Christopher Zacko, M.D.
Principal Investigator:  Adnan I. Qureshi, M.D., Department of Neurology
Primary Site:  University of Minnesota
Role:  Site Principal Investigator
Co-Investigators:  Raymond K. Reichwein, M.D., Department of Neurology, Robert E. Harbaugh, M.D., Kevin M. Cockroft, M.D., Jonas M. Sheehan, M.D., James McInerney, M.D., G. Timothy Reiter, M.D., Kimberly S. Harbaugh, M.D.
Title:  "A Phase III Randomized Multicenter Clinical Trial of Blood Pressure Reduction for Hypertension in Acute Intracerebral Hemorrhage – ATACH-II"
Funding Agency:  National Institutes of Neurological Disorders and Stroke
Period:  06/22/2011-07/31/2013
Amount:  $4,674
Supplemental Funds:  $39,590