Penn State Hershey Clinical Nutrition

Clinical Nutrition runs an active research program with a primary focus on:

  • Energy
  • Expenditure in health
  • Disease

We have eight IRB-approved research studies. The topics of these studies include:

  • Prediction of energy expenditure in critically ill patients
  • Prediction of energy expenditure in acutely ill patients
  • Prediction of energy expenditure in hemodialysis patients
  • Validation of measurement equipment
  • Carbon dioxide release during certain modes of mechanical ventilation
  • Impact of nutrition on the risk of pressure ulcer development

  1. Resting metabolic rate in critical care patients (equation development and validation).
  2. Resting metabolic rate in acute care patients (equation development and validation).
  3. Resting metabolic rate in hemodialysis patients (equation development and validation).
  4. Validation of Quark RMR indirect calorimeter.
  5. Correlation of a dead space ventilation equation with clinical outcomes in critical care.
  6. Follow-up validation of a hand-held calorimeter (simultaneous measurements).
  7. Spontaneous breathing during airway pressure release ventilation.
  8. Role of nutrition and other factors of the Braden score to predict pressure ulcer risk.

  1. Ashcraft CM, Frankenfield DC. Energy expenditure in barbiturate coma.  Nutrition in Clinical Practice (accepted June 2013).
  2. Frankenfield DC.  Bias and accuracy of resting metabolic rate equations in non-obese and obese adults.  Clin Nutr 2013 (accepted).  DOI 10.1016/j.clnu.2013.03.022
  3. Frankenfield DC, Ashcraft CM, Galvan DA.  Prediction of resting metabolic rate in critically ill patients at the extremes of body mass index.  Journal of Parenteral and Enteral Nutrition 2013;37:361-367. DOI:10.1177/0148607112457423.
  4. Frankenfield DC, Schubert A.  An evaluation of a hand-held indirect calorimeter against a standard calorimeter in obese and non-obese adults.  Journal of Parenteral and Enteral Nutrition (accepted December 2012).  DOI 10.1177/0148607112473340
  5. Frankenfield DC, Ashcraft CM, Galvan DA.  Longitudinal prediction of metabolic rate in critically ill patients.  Journal of Parenteral and Enteral Nutrition.  2012;36:700-712.
  6. Frankenfield DC, Ashcraft CM.  Description and prediction of resting metabolic rate after stroke and traumatic brain injury.  Nutrition 2012;28:906-911.
  7. Cooney RN, Frankenfield DC.  Determining energy needs in critically ill patients:  equations or indirect calorimeters.  Curr Opinion Crit Care 2012;18:174-177.  DOI 10.1097/MCC.0b013e32835 14bbc.
  8. Frankenfield DC, Ashcraft CM.  Estimating energy needs in nutrition support patients.  Journal of Parenteral and Enteral Nutrition 2011;35:563-570.
  9. Frankenfield DC.  Validation of a metabolic rate equation in older obese critically ill people.  Journal of Parenteral and Enteral Nutrition 2011;35:264-269.