Division of Musculoskeletal Sciences

History:  The Musculoskeletal Research Laboratory was created in June of 1994 and focused on the investigation of Musculoskeletal adaptation at the organ, tissue, cellular, and molecular levels.  In 2005, the Division of Musculoskeletal Sciences (DOMS) was created to accommodate the expanded scope of basic science, translational research and regenerative medicine interests within the Department of Orthopaedics.

The DOMS is comprised of six faculty principal investigators and clinical faculty with diverse interests in musculoskeletal biology and orthopaedic bioengineering.  A scientific staff of more than 25 research technicians, postdoctoral fellows, graduate and undergraduate students and administrative staff make up this multidisciplinary team.  Orthopaedic residents and medical students are actively involved in both basic science and clinical faculty sponsored projects.

Research within the DOMS is unique in that an integrative multidisciplinary approach is utilized to address issues of musculoskeletal biology and pathology. Musculoskeletal biology is studied at the molecular, cellular, tissue, organ, and whole animal level. This unique perspective offers the resident a diverse learning experience in virtually any area of contemporary research.

Specific Research Interests of the Faculty Include:

  • Molecular Biology of Cartilage Development and Osteoarthritis
  • Transgenic Animal Models of Musculoskeletal Disease
  • Bone and Cartilage Cell Biology
  • Biophysical Signal Transduction as it Applies to Orthopaedic Problems
  • Pathophysiology of Age-Related and Post-Menopausal Osteoporosis
  • Computational Biomechanics
  • Effects of Exercise on Bone and Cartilage
  • Assessment of Orthopaedic Implant Function and Failure
  • Matrix Metalloproteinase Expression in Connective Tissue

Clinical research projects include investigation into thromboembolic disease, heterotopic ossification, and clinical outcome studies of implants and specific operative procedures. 

The DOMS functions within 5,000 square feet of laboratory space that is fully equipped for state-of-the-art cell and molecular biology, mechanical engineering and computational biomechanics.  For more about our facilities, follow this link.

The Division of Musculoskeletal Sciences is strongly committed to graduate education for graduate students, postdoctoral fellows and residents.