Clinical Pathology Laboratories and Services

The Division of Clinical Pathology is composed of eight faculty members, each responsible for one of the service areas of the Medical Laboratory. The Medical Laboratory performs more than 1.5 million tests each year reflecting the diverse make-up of patients seen at this academic care center and the extensive outpatient population. The laboratory includes units for Blood Bank/Apheresis, Microbiology, Virology, Hematology, Chemistry, HLA/Immunology, Laboratory Information Systems, Phlebotomy/Specimen Collection and Central Processing.

Blood Bank, Apheresis, and Transfusion Medicine

Phone:  717-531-8232

Medical Director: Melissa R. George, D.O.

  • Irradiation of blood products
  • Antibody ID's and titers
  • Prenatal testing
  • Donor testing
  • RHIG preventive therapy (dispensed, not administered)
  • Leukoreduction by filtration
  • Therapeutic apheresis [Requires consultation]
  • Therapeutic phlebotomy [Requires consultation]
  • Direct Antiglobulin Testing (DAT or Coombs' Test)
  • Transfusion Medicine consultation/expertise


Clinical Chemistry

Phone:  717-531-8615

Medical Director:  William J. Castellani, M.D.

  • Routine chemistry profiles and panels.
  • Therapeutic drug monitoring.
  • Blood gas analysis; cooximetry; and whole blood testing for glucose, lactate and ionized calcium.
  • Thyroid and fertility testing.
  • Diabetes testing including hemoglobin A1C and microalbumin.
  • Cyclosporine and FK506 testing.
  • Sweat tests for cystic fibrosis screening, performed on outpatients twice a week by appointment and as needed on inpatients.
  • Infectious disease testing including hepatitis, HCV and HIV markers.
  • Wide variety of specialty tests, including intra-operative PTH and fetal fibronectin.
  • Tumor markers including PSA, CA-125, and AFP.
  • Cardiac markers - Troponin I, Myoglobin, CKMB and homocysteine.
  • Inflammatory and nutritional markers.
  • Serum/urine protein and immunofixation electrophoresis, hemoglobin electrophoresis, and associated tests including serum immunoglobulins, hemoglobin A2 and hemoglobin F quantitation.
  • Toxicology screening for drugs of abuse.


Hematology, Thrombosis, and Hemostasis

Phone:  717-531-8115

Medical Director of Hematology and Thrombosis: Keri J. Donaldson, M.D.
Medical Director of Hemostasis: M. Elaine Eyster, M.D.

  • Automated CBC, platelet, and 5 part differential.
  • Reflex manual differentials performed by staff experienced in abnormal cell morphology.
  • Reflex or orderable review by pathologist.
  • Examination for blood parasites.
  • Reticulocyte analysis by flow cytometry.
  • Automated coagulation testing: aPTT, PT, fibrinogen and quantitative D-dimer.
  • Specialized assays for the diagnosis and treatment of disorders of thrombosis, with physician interpretation: Protein S, Protein C, Antithrombin III, Activated Protein C Resistance, Lupus Anticoagulant Testing, and Mixing Studies.
  • Specialized assays for the diagnosis and treatment of disorders of hemostasis: Factor Analysis, Factor Screens, Factor Inhibitors, Heparin (Xa) Assay, Fletcher Factor Screen, Russell Venom Viper Time.



Phone:  717-531-8115

  • Urine and serum pregnancy screen (Same day service).
  • Spinal, serous, synovial, dialysate fluid cell counts and differentials.
  • Synovial crystal examination.
  • Kleihauer Betke fetal cell stain.
  • Occult blood screen (stool and gastric).
  • Urinalysis with reflex microscopic examination.
  • Routine urinalysis with routine microscopic examination.
  • Osmolality on serum and urine.


Special Hematology

Phone:  717-531-8559

Medical Director, Hematopathology: Michael G. Bayerl, M.D.
Medical Director, Hepatitis and HIV Testing: M. Elaine Eyster, M.D.

The Special Hematology laboratory offers the following clinical tests to outreach customers. A courier is available for same day delivery of specimens within a 40 miles radius of our laboratory. The following services are provided by our facility.

  • Comprehensive evaluation of blood and bone marrow specimens for benign and malignant diseases.
  • Flow cytometry testing
    • Leukemia phenotyping
    • Lymphoma phenotyping
    • Myeloma diagnosis and MRD
    • Sezary syndrome
    • PNH testing
    • Lymphocyte subset analysis and immune panel
  • Qualitative and Quantitative testing for Hepatitis C – RNA
  • Quantitative testing for HIV – RNA (Viral load)
  • Hepatitis C gentotyping
  • HIV genotyping for drug resistance
  • Platelet aggregation studies
Physician's interpretation/impression is available for the above tests.



Phone:  717-531-5113

Medical Director:  David W. Craft, Ph.D., D(ABMM)

  • Rapid Strep A antigen detection.
  • DNA probe system for identification of Mycobacterium tuberculosis, M. Gordonae and M. avium-intracellulare complex.
  • Gas chromatography (IDS) identification of unusual gram negative rods, gram positive organisms and other Mycobacterium species.
  • Rapid (4 hour) identification of fermenter and non-fermenter gram negative rods, yeasts, anaerobic bacteria, Neisseria gonorrhea, Hemophilus species and Gardnerella.
  • Rapid identification of methicillin resistant staph aureus.
  • Continuous monitoring system for blood cultures.
  • MIC sensitivities for yeasts and TB.
  • Enhanced recovery and more rapid TAT for the isolation of acid fast bacilli.
  • Fecal leukocyte detection.



Phone:  717-531-5118

Medical Director: Ronald E. Domen, M.D. 
Associate Director: Hiroko Shike, M.D.

  • The Histocompatibility Laboratory performs all Histocompatibility testing required for solid organ and bone marrow transplant programs. This testing consists of state-of-the-art serological and molecular typing for all W.H.O. recognized antigens of the HLA A, B, C, DR and DQ loci. In addition, various types of white cell crossmatching and antibody screening are performed to determine whether or not a potential transplant recipient has antibodies directed against HLA antigens, and in particular, those of a specific donor.

This laboratory provides centralized Histocompatibility services for the entire region served by the Gift of Life donor transplant program.

  • HLA typing (at a nominal cost) for individuals that volunteer as potential donors for the National Marrow Donor Program. HLA tissue typing is also requested for Disease Association studies, when the presence or absence of a particular antigen is informative, e.g. HLA B27 in ankylosing spondylitis.



Phone:  717-531-5121

Medical Director: Wallace H. Greene, Ph.D., D(ABMM)

  • The Clinical Virology Laboratory offers a comprehensive service for viral isolation, rapid direct detection with viral diagnostic assays and viral serologies.
  • The lab offers technical and scientific expertise and support by working closely with the health care provider to determine the most appropriate and cost effective course of action. The laboratory is in operation Monday through Friday, 0800 - 1630 hours, Saturday 0800 - 1200 hours and Sunday 1300 - 1600 hours.
  • All positive results are telephoned to the requesting physician. Special instructions in collection techniques are provided by the virology staff. In addition all viral collection supplies provided at no cost.
  • We offer isolation and identification for the following viruses: adenovirus, cytomegalovirus, enterovirus, herpes simplex virus, influenza virus, parainfluenza virus, mumps, measles, rotavirus, respiratory syncytial virus, and varicella-zoster virus.
  • Molecular diagnostic assays for chlamydia and Neisseria gonorrhea are available.
  • Because our virology lab is within the medical center we achieve optimal sensitivity with viral cultures due to decreased transport times. We are also readily available for on-site or phone consultations.


Pathology Core Reference Lab

Phone:  717-531-8317

Medical Director:  William J. Castellani, M.D.

  • DABCCOur core endocrine laboratory provides comprehensive specialty hormone analysis such as insulin (total and free), pro-insulin, PTH (intact), androstenedione, aldosterone, 17 OH Progesterone, DHEA-S, ACTH, HGH, IGF-1, IGF-BP3, free testosterone and other analytes such as estriol, N-telopeptide, bone specific alkaline phosphatase and renin activity.



Michael H. Creer, M.D.
Professor and Chief of Clinical Pathology
Director, Clinical Laboratory
Pathology Residency Program Director

Thomas W. Abendroth, M.D.
Associate Professor
Chief Information Officer 

William J. Castellani, M.D.
Medical Director, Clinical Chemistry
Director, Pathology Core Reference Lab
Associate Director, Pathology Residency Program

David W. Craft, Ph.D., D(ABMM)
Associate Professor
Medical Director, Microbiology Laboratory

Ronald E. Domen, M.D.
Professor of Pathology, Medicine and Humanities
Director, Histocompatibility Laboratory
Program Director, Blood Banking/Transfusion Medicine Fellowship
Associate Dean for Graduate Medical Education and DIO

Keri J. Donaldson, M.D.
Assistant Professor
Medical Director, Hematology and Thrombosis Laboratory
Medical Director, Molecular Diagnostic Laboratory

Melissa R. George, D.O.
Assistant Professor
Medical Director, Blood Bank

Wallace H. Greene, Ph.D., D(ABMM)
Associate Professor
Scientific Director, Clinical Virology Laboratory

Mary Beth Miele, Ph.D.
Education Coordinator and Instructor
Pathology Residency Coordinator

Hiroko Shike, M.D.
Assistant Professor
Associate Director, Histocompatibility Laboratory
Medical Director, PSU State College Laboratory