Ecuador Mission Program (Clinical)

Over the last 15 years, the Penn State Children's Hospital has annually deployed a team of specialists (including pediatric heart surgeons, cardiologists, anesthesiologists, intensivists, perfusionists, nurses, and medical students) to perform life-saving heart surgery for children at the Hospital de los NiƱos in Guayaquil, Ecuador.   In addition to the providing a charitable clinical service, the team also continues to provide direct education to the local surgeons and clinicians, with the goal of fostering an independent, self-sustaining pediatric heart surgery program at our Children's Hospital. 

International Conference on Pediatric Mechanical Circulatory Support Systems & Pediatric Cardiopulmonary Perfusion (Clinical/ Basic Science/ Engineering)

The main objective of this conference is to focus on the current problems associated with pediatric cardiac patients during and after acute or chronic cardiac support. In this conference, we bring together as many distinguished physicians and scientists as possible, in order to precisely define the current problems and to suggest solutions with novel approaches. During the past 12 events (2005-2016), over 3,000 participants from 34 countries appreciate 1,049 presentations along with over 435 peer-reviewed publications including original articles, editorials, special reports, letters and case reports.

International Conference website

Impact of Pulsatile CPB on Vital Organ Recovery (Clinical/ Basic Science/ Engineering)

This study is designed to investigate the effects of pulsatile flow versus conventional non-pulsatile flow on systemic inflammation, and cerebral, myocardial, renal, and pulmonary recovery at different temperatures in neonates and infants during CPB.

Application of real time intra-operative neurologic monitoring on management of pediatric cardiopulmonary bypass (Clinical)

The objective of this research is to incorporate advanced neurologic monitoring techniques using a multi-disciplinary team approach to proactively identify and mitigate high risk periods during pediatric cardiopulmonary bypass.

Microemboli Detection and Classification by Innovative Ultrasound Technology During Cardiopulmonary Bypass Procedures (Clinical/ Engineering)

The objective of this study is to detect and classify the number and size of gaseous microemboli during normothermic, hypothermic and deep-hypothermic cardiopulmonary bypass.

Evaluation of hemodynamic performance of a combined ECLS and CRRT circuit in seven positions with a simulated neonatal patient (Clinical/ Engineering)

Since it is common for patients treated with extracorporeal life support (ECLS) to subsequently require continuous renal replacement therapy (CRRT), and neonatal patients encounter limitations due to lack of access points, inclusion of CRRT in the ECLS circuit could provide advanced treatment for this population. The objective of this study is to evaluate an alternative neonatal extracorporeal life support (ECLS) circuit containing either a centrifugal pump or roller pump with one of seven configurations of CRRT using the Prismaflex 2000 System.

Evaluation of Neonatal/Pediatric/Adult Hollow-fiber Membrane Oxygenators on Hemodynamic Performance and Gaseous Microemboli Handling: An International Multicenter/ Multidisciplinary Approach (Clinical/ Engineering)

The objective of this study is to compare the hemodynamic performances and gaseous microemboli (GME) handling ability of several neonatal/pediatric/adult oxygenators in a simulated cardiopulmonary bypass (CPB) models and the importance of adding an arterial filter in the CPB circuits.

Building a Better Neonatal ECLS Circuit: Comparison of Hemodynamic Performance and Gaseous Microemboli Handling in Different Pump and Oxygenator Technologies (Clinical/ Engineering)

The objective of this study is to evaluate hemodynamic performance and GME handling using an alternative neonatal ECLS circuit with two different pumps and polymethylpentene oxygenators in addition to the Better-Bladder in a simulated neonatal ECLS system.

Neonatal/Pediatric/Adult Extracorporeal Life Support Systems with Pulsatile and Non-Pulsatile flow:  Research and Education at Penn State Children's Hospital (Clinical/ Engineering)

The main objective of this proposal is to educate and train clinicians, with next generation ECLS oxygenators and blood pumps.

Discovery Proteomics During Pediatric Cardiac Surgery (Clinical/ Basic Science)

These studies use state-of-the art two-dimensional gel electrophoresis, liquid chromatography, and mass spectrometry along with multi-analyte profile immunoassays to identify altered serum proteins resulting from CPB perfusion modes. In addition, these studies may lead to the identification of specific preclinical markers that are associated with short- and long-term outcomes that can be used to further optimize strategies for CPB in high-risk pediatric populations.