Inherited immunodeficiency disorders are some of the most common diseases stem cell transplantation is used for in pediatrics. The purpose of stem cell transplantation for these disorders is to replace defective immune cells with healthy stem cells that will eventually grow and produce normal immune cells. Two of the most common immunodeficiency disorders treated at the Pediatric Stem Cell Transplant Program here at Penn State are severe combined immune deficiency disorder (SCIDS) and Wiskott Aldrich syndrome. The type of transplant and the pre-transplant regimen used vary based on the patient's clinical situation. Sometimes the decision is made to give chemotherapy prior to the infusion of stem cells to make space for the transplanted stem cells to grow. Our dedicated team of transplant physicians and immunologists will work with you and your child through the diagnostic evaluation phase of your child’s illness to determine which type of immune deficiency disorder your child may have, and which type of transplant would be in your child's best interest. The pediatric stem cell transplant staff at Penn State Children's Hospital have many years of experience in caring for patients with inherited immune deficiency disorders, and have achieved excellent results in patients receiving stem cell transplant for these disorders. As with all of our patients undergoing stem cell transplant, these children are cared for before and after the transplant in our specialized inpatient and outpatient stem cell transplant units.