Physiology - Highlights

Our faculty have been recipients of numerous NIH Awards, NASA Awards, Research Career Development Awards, MERIT Awards, and Endowed Professorships; they have achieved world-wide recognition for pioneering research accomplishments.

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Exciting new paper from Candice M. Klingerman, Michelle E. Stipanovic, Mohammad Bader and Christopher J. Lynch investigates metabolic side effects of neuroleptics. Read it at the link below:
http://schizophreniabulletin.oxfordjournals.org/content/early/2013/01/17/schbul.sbs196.full?keytype=ref&ijkey=7rZXCDReK8zIs2l

 

"Pore" over this new paper by Zhe Li, He Huang, Bo Yang, Hong Jiang, Guo-Feng Gao, Blaise Z. Peterson, Cong-Xin Huang on Amino acid substitutions in the pore affect the anomalous mole fraction effect of CaV1.2 channels Mol Med Report. 2013 Feb;7(2):571-6. doi: 10.3892/mmr.2012.1210. Epub 2012 Nov 30. http://www.ncbi.nlm.nih.gov/pubmed/23229127

 

Three new papers have appeared from Jefferson and Kimball group. The first is first authored by Andrew Kelleher. The second by Michael Dennis. Another is first authored by Yan Cheng. Congratulations on these papers!
1) mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. Kelleher AR, Kimball SR, Dennis MD, Schilder RJ, Jefferson LS.
Am J Physiol Endocrinol Metab. 2012 Nov 27.
http://www.ncbi.nlm.nih.gov/pubmed/23193052

2) Mechanistic target of rapamycin in complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. Dennis MD, Kimball SR, Jefferson LS. J Biol Chem. 2012 Nov 26. [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23184952

3) Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, Kimball SR, Harvey H, Jefferson LS, Yang JM. Autophagy. 2012 Nov 26;9(2). [Epub ahead of print]
http://www.ncbi.nlm.nih.gov/pubmed/23182879