Publications

  1. Erickson, KK, Sundstrom, JM, Antonetti, DA. Vascular Permeability in Ocular Disease and the Role of Tight Junctions. Angiogenesis. In press.
  2. Zinnanti, WJ, Lazovic, J, Wolpert, EB, Antonetti, DA, Smith, MB, Connor, JR, Woontner, M, Goodman, SI, Cheng, KC. A diet-induced mouse model fro glutaric aciduria type I. Brain  129:899-910., 2006.
  3. Barber, AJ, Gastinger, MJ, VanGuilder, HD. In, Torriglia, A, Crisanti-Lassiaz, P. (Eds.)  Apoptosis in Diabetic Retinopathy, Chapter 4: Apoptosis in the Retina. Transworld Research Network, Kerala, India, pp63-88, 2006.
  4. Gardner, TW, Jackson, GR, Quillen, DA, Scott, IU,. Diabetic Retinopathy: Translating Discoveries to Treatments. In, Greenbaum, C, Harrison, LC. (Eds.). Diabetes: translating discoveries into practice. Informa. New York, in press.
  5. Timothy, NH, Sun, JK, Cavallerano, J, Gardner, TW, Aiello, LP. Future Therapies: Rationale for and Status of Anti-permeability Interventions. In, Scott, IU, Flynn, HF, Smidy, W. (Eds.). Diabetes and Ocular Disease: Past, Present, and Future Therapies, 2nd ed., American Academy of Ophthalmology monograph, in press.
  6. Fort, PE, Singh, RSJ, Losiewicz, MK, Gardner, TW, Insulin receptor-based signaling in the retina: Functional analysis and implications for retinal disease. In, Fliesler, SJ, Kisseley, O,. CRC Press, Boca Raton, In press.
  7. PKC-DMES Study Group. Effect of ruboxistaurin, a PKC beta-selective inhibitor, in patients with diabetic macular edema: 30 month results of the randomized PKC-DMES clinical trial. Arch Ophthamol. In press.
  8. Gardner, TW, Aiello, LP, Pathogenesis of diabetic retinopathy. In, Scott, IU, Flynn, HF, Smiddy, W (Eds.). Diabetic and Ocular Disease: Past, Present, and Future Therapies, 2nd ed., American Academy of Ophthalmology monograph, in press.
  9. Hong, E-G, Jung, DY, Ko, HJ, Zhang Z, Ma, Z, Summer, AD, Vary, TC, Gardner TW, Bronson, SK, Kim JK.  Nonobese Ins2Akita mice develop Type 2 diabetes phenotypes including insulin resistance and cardiac remodeling. Submitted.
  10. Gardner, TW, Antonetti, DA, A prize catch for diabetic retinopathy. Nature Med. 13: 131-132, 2007.
  11. Maines, LE., French, KJ., Wolpert, EB., Antonetti, DA., Smith, CD. Pharmacologic inhibition of sphingosine kinase in retinal endothelial cells: implications for diabetic retinopathy.  Invest Ophthalmol Vis Sci. 47(11):5022-31, 2006
  12. Gardner, TW., Sander, B., Larsen, ML., Kunselman, A., TenHave, T., Lund-Andersen, H., Reimers, J., Hubbard, L., Davis, MD.,  Blankenship, GW., Quillen, DA., Brod, RD., Wilmarth, MH., Post-Hansen, H., Parving, H-H. An Extention of the Early Treatment Diabetic Retinopathy Study (ETDRS) System for Grading of Diabetic Macular Edema in the Astemizole Retinopathy Trial. Curr Eye Res 31:353-547, 2006
  13. PKC-DMES Study Group. Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy Ophthalmol.  2006
  14. Gardner, TW., Antonetti, DA. Ruboxistaurin  for diabetic retinopathy. Ophthalmology. 113(12):2135-36, 2006
  15. Xu, Y., Ola, MS., Berkich, DA., Gardner, TW., Barber, AJ., Palmieri, F., Hutson, SM., LaNoue, KF.  Energy sources for glutamate neurotransmission in the retina: Absence of the aspartate/glutamate carrier produces reliance on glycolysis in glia. J Neurochem in press
  16. Fox, TE., Han, X., Kelly, S., Merrill, AH., Martin, RE., Anderson, RE., Gardner, TW, Kester, M. Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy. Diabetes  55(12):3573-80, 2006
  17. Antonetii, DA., Barber, AJ., Bronson, SK., Freeman, WM., Gardner, TW., Jefferson, LS., Kester, M., Kimball, SR., Krady, JK., Norbury, CC., Quinn, PG., Sandirasegarane, L., Simpson, IA. Diabetic Retinopathy: seeing beyond glucose-induced microvascular disease. Diabetes 55: 2401-2411, 2006
  18. Gastinger, MJ., Singh, RS., Barber, AJ. Loss of cholinergic and dopaminergic amacrine cells instreptozotocin-diabetic rat and Ins1Akita-diabetic mouse retinas. Invest Ophthalmol Vis Sci 47:3143-50, 2006
  19. Santiago, AR., Rosa, SC., Santos, PF., Cristovao, AJ., Barber, AJ., Ambrosio, AF., Elevated glucose changes the expression in ionotropic glutamate receptor subunits and impairs calcium homeostasis in retinal neural cells. Invest Ophthalmol Vis Sci 47:4130-7, 2006
  20. Harhaj, NS., Felinski F., Wolpert, EB., Sundstrom JM, Gardner, TW, Antonetti, DA. VEGF activation of protein kinase C stimulates occulin phosphorylation and contributes to endothelial permeability. Invest Ophthalmol Vis Sci 47(11):5106-15, 2006
  21. Crozier, S., J. Anthony, C. Schworer, A. Reiter, T. Anthony, S. Kimball, and L. Jefferson, Essentially of free fatty acids for the maintenance of protein synthesis in the heart during insulin deficiency. 2006: p. submitted.
  22. Antonetti, D.A., A.J. Barber, and T.W. Gardner, Blood retina barrier. In, Jaffe GJ., Ashton P., Pearson PA., (eds),  Intraocular Drug Delivery: Principles and Clinical Applications. NY, Taylor & Francis, 2006, pp 27-40.
  23. Reiter, C.E., L. Sandirasegarane, X. Wu, M. Nakamura, D.A. Antonetti, and T.W. Gardner, Diabetes reduces constitutive retinal insulin receptor signaling: reversal with systemic and local insulin. Diabetes 55: 1148-1156, 2006
  24. Kline, C.L., T.L. Schrufer, L.S. Jefferson, and S.R. Kimball, Glucosamine-induced phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 is mediated by the protein kinase R-like endoplasmic-reticulum associated kinase. Int J Biochem Cell Biol, 2006. 38(5-6): p. 1004-14.
  25. Basile, M., R. Lin, N. Kabbani, K. Karpa, M. Kilimann, I. Simpson, and M. Kester, Paralemmin interacts with D3 dopamine receptors: implications for membrane localization and cAMP signaling. Arch Biochem Biophys, 2006. 446(1): p. 60-8.
  26. Weber, W.M., L.A. Hunsaker, C.N. Roybal, E.V. Bobrovnikova-Marjon, S.F. Abcouwer, R.E. Royer, L.M. Deck, and D.L. Vander Jagt, Activation of NFkappaB is inhibited by curcumin and related enones. Bioorg Med Chem, 2006. 14(7): p. 2450-61.
  27. Reiley, W.W., M. Zhang, W. Jin, M. Losiewicz, K.B. Donohue, C.C. Norbury, and S.C. Sun, Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol, 2006.
  28. Truckenmiller, M.E., R.H. Bonneau, and C.C. Norbury, Stress presents a problem for dendritic cells: Corticosterone and the fate of MHC class I antigen processing and presentation. Brain Behav Immun, 2006.
  29. Gastinger, M.J., A.J. Barber, N. Vardi, and D.W. Marshak, Histamine receptors in mammalian retinas. J Comp Neurol, 2006. 495(6): p. 658-67.
  30. Huang, X. and T.L. Lowe, Biodegradable thermoresponsive hydrogels for aqueous encapsulation and controlled release of hydrophilic model drugs. Biomacromolecules, 2005. 6(4): p. 2131-9.
  31. Stover, T.C., A. Sharma, G.P. Robertson, and M. Kester, Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma. Clin Cancer Res, 2005. 11(9): p. 3465-74.
  32. Hutson, S.M., A.J. Sweatt, and K.F. Lanoue, Branched-chain [corrected] amino acid metabolism: implications for establishing safe intakes. J Nutr, 2005. 135(6 Suppl): p. 1557S-64S.
  33. Berkich, D.A., Y. Xu, K.F. LaNoue, R. Gruetter, and S.M. Hutson, Evaluation of brain mitochondrial glutamate and alpha-ketoglutarate transport under physiologic conditions. J Neurosci Res, 2005. 79(1-2): p. 106-13.
  34. Ola, M.S., D.A. Berkich, Y. Xu, M.T. King, T.W. Gardner, I. Simpson, and K.F. Lanoue, Analysis of glucose metabolism in diabetic rat retinas. Am J Physiol Endocrinol Metab, 2006. 290(6): E1057-672005.
  35. Weber, W.M., L.A. Hunsaker, S.F. Abcouwer, L.M. Deck, and D.L. Vander Jagt, Anti-oxidant activities of curcumin and related enones. Bioorg Med Chem, 2005. 13(11): p. 3811-20.
  36. Roybal, C.N., L.A. Hunsaker, O. Barbash, D.L. Vander Jagt, and S.F. Abcouwer, The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism. J Biol Chem, 2005. 280(21): p. 20331-9.
  37. Roybal, C.N., L.Y. Marmorstein, D.L. Vander Jagt, and S.F. Abcouwer, Aberrant accumulation of fibulin-3 in the endoplasmic reticulum leads to activation of the unfolded protein response and VEGF expression. Invest Ophthalmol Vis Sci, 2005. 46(11): p. 3973-9.
  38. Gariano, RF., Gardner, TW. Angiogenesis in Retinal Development and Retinal Diseases. Nature 438:960-966, 2005
  39. Lazovic, J., A. Basu, H.W. Lin, R.P. Rothstein, J.K. Krady, M.B. Smith, and S.W. Levison, Neuroinflammation and both cytotoxic and vasogenic edema are reduced in interleukin-1 type 1 receptor-deficient mice conferring neuroprotection. Stroke, 2005. 36(10): p. 2226-31.
  40. Krady, J.K., A. Basu, C.M. Allen, Y. Xu, K.F. LaNoue, T.W. Gardner, and S.W. Levison, Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes, 2005. 54(5): p. 1559-65.
  41. Basu, A., J. Lazovic, J.K. Krady, D.T. Mauger, R.P. Rothstein, M.B. Smith, and S.W. Levison, Interleukin-1 and the interleukin-1 type 1 receptor are essential for the progressive neurodegeneration that ensues subsequent to a mild hypoxic/ischemic injury. J Cereb Blood Flow Metab, 2005. 25(1): p. 17-29.
  42. Truckenmiller, M.E., M.F. Princiotta, C.C. Norbury, and R.H. Bonneau, Corticosterone impairs MHC class I antigen presentation by dendritic cells via reduction of peptide generation. J Neuroimmunol, 2005. 160(1-2): p. 48-60.
  43. Pang, Z., D.A. Antonetti, and J.M. Tarbell, Shear stress regulates HUVEC hydraulic conductivity by occludin phosphorylation. Ann Biomed Eng, 2005. 33(11): p. 1536-45.
  44. Maines, L.W., D.A. Antonetti, E.B. Wolpert, and C.D. Smith, Evaluation of the role of P-glycoprotein in the uptake of paroxetine, clozapine, phenytoin and carbamazapine by bovine retinal endothelial cells. Neuropharmacology, 2005. 49(5): p. 610-7.
  45. Felinski, E.A. and D.A. Antonetti, Glucocorticoid regulation of endothelial cell tight junction gene expression: novel treatments for diabetic retinopathy. Curr Eye Res, 2005. 30(11): p. 949-57.
  46. Barber, A.J., D.A. Antonetti, T.S. Kern, C.E. Reiter, R.S. Soans, J.K. Krady, S.W. Levison, T.W. Gardner, and S.K. Bronson, The Ins2Akita mouse as a model of early retinal complications in diabetes. Invest Ophthalmol Vis Sci, 2005. 46(6): p. 2210-8.
  47. Huang, X., B.R. Nayak, and T.L. Lowe, Synthesis and Characterization of Novel Thermoresponsive-co-Biodegradable Hydrogels Composed of N-isopropylacrylamide, Poly(I-lactic acid), and Dextran. Journal of Polymer Science Part A: Plymer Chemistry, 2004. 42: p. 5054-5066.
  48. Zhang, L., A. Nair, K. Krady, C. Corpe, R.H. Bonneau, I.A. Simpson, and S.J. Vannucci, Estrogen stimulates microglia and brain recovery from hypoxia-ischemia in normoglycemic but not diabetic female mice. J Clin Invest, 2004. 113(1): p. 85-95.
  49. Xu, Y., G. Oz, K.F. LaNoue, C.J. Keiger, D.A. Berkich, R. Gruetter, and S.H. Hutson, Whole-brain glutamate metabolism evaluated by steady-state kinetics using a double-isotope procedure: effects of gabapentin. J Neurochem, 2004. 90(5): p. 1104-16.
  50. Oz, G., D.A. Berkich, P.G. Henry, Y. Xu, K. LaNoue, S.M. Hutson, and R. Gruetter, Neuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity. J Neurosci, 2004. 24(50): p. 11273-9.
  51. Fong, D.S., L. Aiello, T.W. Gardner, G.L. King, G. Blankenship, J.D. Cavallerano, F.L. Ferris, 3rd, and R. Klein, Retinopathy in diabetes. Diabetes Care, 2004. 27 Suppl 1: p. S84-7.
  52. Stahl, J.M., A. Sharma, M. Cheung, M. Zimmerman, J.Q. Cheng, M.W. Bosenberg, M. Kester, L. Sandirasegarane, and G.P. Robertson, Deregulated Akt3 activity promotes development of malignant melanoma. Cancer Res, 2004. 64(19): p. 7002-10.
  53. Wickenheisser, J.K., V.L. Nelson-DeGrave, P.G. Quinn, and J.M. McAllister, Increased cytochrome P450 17alpha-hydroxylase promoter function in theca cells isolated from patients with polycystic ovary syndrome involves nuclear factor-1. Mol Endocrinol, 2004. 18(3): p. 588-605.
  54. Roybal, C.N., S. Yang, C.W. Sun, D. Hurtado, D.L. Vander Jagt, T.M. Townes, and S.F. Abcouwer, Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J Biol Chem, 2004. 279(15): p. 14844-52.
  55. Marjon, P.L., E.V. Bobrovnikova-Marjon, and S.F. Abcouwer, Expression of the pro-angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 by human breast carcinomas is responsive to nutrient deprivation and endoplasmic reticulum stress. Mol Cancer, 2004. 3: p. 4.
  56. Bobrovnikova-Marjon, E.V., P.L. Marjon, O. Barbash, D.L. Vander Jagt, and S.F. Abcouwer, Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: role of nuclear factor-kappaB and activating protein-1. Cancer Res, 2004. 64(14): p. 4858-69.
  57. Basu, A., J.K. Krady, and S.W. Levison, Interleukin-1: a master regulator of neuroinflammation. J Neurosci Res, 2004. 78(2): p. 151-6.
  58. Norbury, C.C., S. Basta, K.B. Donohue, D.C. Tscharke, M.F. Princiotta, P. Berglund, J. Gibbs, J.R. Bennink, and J.W. Yewdell, CD8+ T cell cross-priming via transfer of proteasome substrates. Science, 2004. 304(5675): p. 1318-21.
  59. Truckenmiller, M.E. and C.C. Norbury, Viral vectors for inducing CD8+ T cell responses. Expert Opin Biol Ther, 2004. 4(6): p. 861-8.
  60. Mostoller, K., C.C. Norbury, P. Jain, and B. Wigdahl, Human T-cell leukemia virus type I Tax induces the expression of dendritic cell markers associated with maturation and activation. J Neurovirol, 2004. 10(6): p. 358-71.
  61. Schwindinger, W.F., K.E. Giger, K.S. Betz, A.M. Stauffer, E.M. Sunderlin, L.J. Sim-Selley, D.E. Selley, S.K. Bronson, and J.D. Robishaw, Mice with deficiency of G protein gamma3 are lean and have seizures. Mol Cell Biol, 2004. 24(17): p. 7758-68.
  62. Heaney, J.D., A.N. Rettew, and S.K. Bronson, Tissue-specific expression of a BAC transgene targeted to the Hprt locus in mouse embryonic stem cells. Genomics, 2004. 83(6): p. 1072-82.
  63. Wu, X., C.E. Reiter, D.A. Antonetti, S.R. Kimball, L.S. Jefferson, and T.W. Gardner, Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner. J Biol Chem, 2004. 279(10): p. 9167-75.
  64. Ohashi, H., H. Takagi, S. Koyama, H. Oh, D. Watanabe, D.A. Antonetti, T. Matsubara, K. Nagai, H. Arai, T. Kita, and Y. Honda, Alterations in expression of angiopoietins and the Tie-2 receptor in the retina of streptozotocin induced diabetic rats. Mol Vis, 2004. 10: p. 608-17.
  65. Harhaj, N.S. and D.A. Antonetti, Regulation of tight junctions and loss of barrier function in pathophysiology. Int J Biochem Cell Biol, 2004. 36(7): p. 1206-37.
  66. DeMaio, L., J.M. Tarbell, R.C. Scaduto, Jr., T.W. Gardner, and D.A. Antonetti, A transmural pressure gradient induces mechanical and biological adaptive responses in endothelial cells. Am J Physiol Heart Circ Physiol, 2004. 286(2): p. H731-41.
  67. DeMaio, L., D.A. Antonetti, R.C. Scaduto, Jr., T.W. Gardner, and J.M. Tarbell, VEGF increases paracellular transport without altering the solvent-drag reflection coefficient. Microvasc Res, 2004. 68(3): p. 295-302.
  68. Stover, T. and M. Kester, Liposomal delivery enhances short-chain ceramide-induced apoptosis of breast cancer cells. J Pharmacol Exp Ther, 2003. 307(2): p. 468-75.
  69. Kester, M. and R. Kolesnick, Sphingolipids as therapeutics. Pharmacol Res, 2003. 47(5): p. 365-71.
  70. Reiter, C.E. and T.W. Gardner, Functions of insulin and insulin receptor signaling in retina: possible implications for diabetic retinopathy. Prog Retin Eye Res, 2003. 22(4): p. 545-62.
  71. Luo, S., P. Baumeister, S. Yang, S.F. Abcouwer, and A.S. Lee, Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements. J Biol Chem, 2003. 278(39): p. 37375-85.
  72. Norbury, C.C. and L.J. Sigal, Cross priming or direct priming: is that really the question? Curr Opin Immunol, 2003. 15(1): p. 82-8.
  73. Erin, N., S.K. Bronson, and M.L. Billingsley, Calcium-dependent interaction of calcineurin with Bcl-2 in neuronal tissue. Neuroscience, 2003. 117(3): p. 541-55.
  74. Bronson, S.K., C.E. Reiter, and T.W. Gardner, An eye on insulin. J Clin Invest, 2003. 111(12): p. 1817-9.
  75. Barber, A.J., A new view of diabetic retinopathy: a neurodegenerative disease of the eye. Prog Neuropsychopharmacol Biol Psychiatry, 2003. 27(2): p. 283-90.
  76. Reiter, C.E., L. Sandirasegarane, E.B. Wolpert, M. Klinger, I.A. Simpson, A.J. Barber, D.A. Antonetti, M. Kester, and T.W. Gardner, Characterization of insulin signaling in rat retina in vivo and ex vivo. Am J Physiol Endocrinol Metab, 2003. 285(4): p. E763-74.
  77. Burdo, J.R., D.A. Antonetti, E.B. Wolpert, and J.R. Connor, Mechanisms and regulation of transferrin and iron transport in a model blood-brain barrier system. Neuroscience, 2003. 121(4): p. 883-90.
  78. Barber, A.J. and D.A. Antonetti, Mapping the blood vessels with paracellular permeability in the retinas of diabetic rats. Invest Ophthalmol Vis Sci, 2003. 44(12): p. 5410-6.
  79. Antonetti, D.A. and E.B. Wolpert, Isolation and characterization of retinal endothelial cells. Methods Mol Med, 2003. 89: p. 365-74.
  80. Bourbon, N.A., L. Sandirasegarane, and M. Kester, Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. J Biol Chem, 2002. 277(5): p. 3286-92.
  81. Abcouwer, S.F., P.L. Marjon, R.K. Loper, and D.L. Vander Jagt, Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress. Invest Ophthalmol Vis Sci, 2002. 43(8): p. 2791-8.
  82. Basu, A., J.K. Krady, M. O'Malley, S.D. Styren, S.T. DeKosky, and S.W. Levison, The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J Neurosci, 2002. 22(14): p. 6071-82.
  83. Norbury, C.C., D. Malide, J.S. Gibbs, J.R. Bennink, and J.W. Yewdell, Visualizing priming of virus-specific CD8+ T cells by infected dendritic cells in vivo. Nat Immunol, 2002. 3(3): p. 265-71.
  84. Harhaj, N.S., A.J. Barber, and D.A. Antonetti, Platelet-derived growth factor mediates tight junction redistribution and increases permeability in MDCK cells. J Cell Physiol, 2002. 193(3): p. 349-64.
  85. Gardner, T.W., D.A. Antonetti, A.J. Barber, K.F. LaNoue, and S.W. Levison, Diabetic retinopathy: more than meets the eye. Surv Ophthalmol, 2002. 47 Suppl 2: p. S253-62.
  86. Antonetti, D.A., E.B. Wolpert, L. DeMaio, N.S. Harhaj, and R.C. Scaduto, Jr., Hydrocortisone decreases retinal endothelial cell water and solute flux coincident with increased content and decreased phosphorylation of occludin. J Neurochem, 2002. 80(4): p. 667-77.
  87. Bourbon, N.A., J. Yun, D. Berkey, Y. Wang, and M. Kester, Inhibitory actions of ceramide upon PKC-epsilon/ERK interactions. Am J Physiol Cell Physiol, 2001. 280(6): p. C1403-11.
  88. Lieth, E., K.F. LaNoue, D.A. Berkich, B. Xu, M. Ratz, C. Taylor, and S.M. Hutson, Nitrogen shuttling between neurons and glial cells during glutamate synthesis. J Neurochem, 2001. 76(6): p. 1712-23.
  89. Hutson, S.M., E. Lieth, and K.F. LaNoue, Function of leucine in excitatory neurotransmitter metabolism in the central nervous system. J Nutr, 2001. 131(3): p. 846S-850S.
  90. Sandirasegarane, L. and M. Kester, Enhanced stimulation of Akt-3/protein kinase B-gamma in human aortic smooth muscle cells. Biochem Biophys Res Commun, 2001. 283(1): p. 158-63.
  91. Gastinger, M.J., A.J. Barber, S.A. Khin, C.S. McRill, T.W. Gardner, and D.W. Marshak, Abnormal centrifugal axons in streptozotocin-diabetic rat retinas. Invest Ophthalmol Vis Sci, 2001. 42(11): p. 2679-85.
  92. LaNoue, K.F., D.A. Berkich, M. Conway, A.J. Barber, L.Y. Hu, C. Taylor, and S. Hutson, Role of specific aminotransferases in de novo glutamate synthesis and redox shuttling in the retina. J Neurosci Res, 2001. 66(5): p. 914-22.
  93. Nakamura, M., A.J. Barber, D.A. Antonetti, K.F. LaNoue, K.A. Robinson, M.G. Buse, and T.W. Gardner, Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. J Biol Chem, 2001. 276(47): p. 43748-55.
  94. DeMaio, L., Y.S. Chang, T.W. Gardner, J.M. Tarbell, and D.A. Antonetti, Shear stress regulates occludin content and phosphorylation. Am J Physiol Heart Circ Physiol, 2001. 281(1): p. H105-13.
  95. Barber, A.J., M. Nakamura, E.B. Wolpert, C.E. Reiter, G.M. Seigel, D.A. Antonetti, and T.W. Gardner, Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. J Biol Chem, 2001. 276(35): p. 32814-21.
  96. Lakshminarayanan, S., T.W. Gardner, and J.M. Tarbell, Effect of shear stress on the hydraulic conductivity of cultured bovine retinal microvascular endothelial cell monolayers. Curr Eye Res, 2000. 21(6): p. 944-51.
  97. Lieth, E., T.W. Gardner, A.J. Barber, and D.A. Antonetti, Retinal neurodegeneration: early pathology in diabetes. Clin Experiment Ophthalmol, 2000. 28(1): p. 3-8.
  98. Gardner, T.W., D.A. Antonetti, A.J. Barber, K.F. LaNoue, and M. Nakamura, New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets. Diabetes Technol Ther, 2000. 2(4): p. 601-8.
  99. Antonetti, D.A., A.J. Barber, L.A. Hollinger, E.B. Wolpert, and T.W. Gardner, Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occludin and zonula occluden 1. A potential mechanism for vascular permeability in diabetic retinopathy and tumors. J Biol Chem, 1999. 274(33): p. 23463-7.
  100. Lieth, E., A.J. Barber, B. Xu, C. Dice, M.J. Ratz, D. Tanase, and J.M. Strother, Glial reactivity and impaired glutamate metabolism in short-term experimental diabetic retinopathy. Penn State Retina Research Group. Diabetes, 1998. 47(5): p. 815-20.
  101. Barber, A.J., E. Lieth, S.A. Khin, D.A. Antonetti, A.G. Buchanan, and T.W. Gardner, Neural apoptosis in the retina during experimental and human diabetes. Early onset and effect of insulin. J Clin Invest, 1998. 102(4): p. 783-91.
  102. Antonetti, D.A., A.J. Barber, S. Khin, E. Lieth, J.M. Tarbell, and T.W. Gardner, Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Diabetes, 1998. 47(12): p. 1953-9.
  103. Barber, A.J. and E. Lieth, Agrin accumulates in the brain microvascular basal lamina during development of the blood-brain barrier. Dev Dyn, 1997. 208(1): p. 62-74.
  104. Gardner, T.W., E. Lieth, S.A. Khin, A.J. Barber, D.J. Bonsall, T. Lesher, K. Rice, and W.A. Brennan, Jr., Astrocytes increase barrier properties and ZO-1 expression in retinal vascular endothelial cells. Invest Ophthalmol Vis Sci, 1997. 38(11): p. 2423-7.
  105. Gardner, T.W., T. Lesher, S. Khin, C. Vu, A.J. Barber, and W.A. Brennan, Jr., Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells. Biochem J, 1996. 320 (Pt 3): p. 717-21.
  106. Gastinger MJ, Barber AJ, Vardi N, Marshak DW (2006) Histamine receptors in mammalian retinas. J Comp. Neurol. 495:658-667.