All faculty direct productive research programs in the area of trauma and organ injury. The faculty have diverse training and research expertise in physiology, molecular biology, pathophysiology, wound healing, bone metabolism and repair, endocrinology and metabolism as well as various aspects of inflammation. In addition, there is a relatively even distribution of basic and physician scientists. The training record of the faculty is exceptionally strong and diverse. We believe that the interdisciplinary approach to research and training is one of the unique strengths of our Program.
Training Faculty (alphabetically by faculty member)
Two programmatic themes are identified based on the active research of the Core and Participating faculty. These areas of excellence include: (1) Metabolism and Endocrinology and (2) Organ Injury and Repair. As evidenced by the subsequent discussion, these divisions are relatively arbitrary, and there is considerable overlap among the themes and expertise of the involved faculty. The following is a brief summary of current research related to trauma and injury biology conducted by Core and some Participating faculty members.
DONAHUE, HENRY J., PhD, is Professor and Vice-Chair of Research, Department of Orthopedics and Rehabilitation, and is interested in the regulation of bone and cartilage cell metabolism by extracellular signals, both chemical and biophysical (mechanical stress), the mechanisms by which these signals interact with cell membranes, and how various stressors affect these processes.
EHRLICH, PAUL, PhD, is Professor of Surgery, and his research focuses on wound healing and scar formation.
FROST, ROBERT A., PhD, is Associate Professor or Cellular & Molecular Physiology, and studies the mechanism of muscle wasting in sepsis and trauma, with special focus on the GH-IGF axis.
JEFFERSON, LEONARD S., PhD, is Professor and Chair, Department of Cellular & Molecular Physiology, and studies the signaling pathways and effector mechanisms through which hormones (especially insulin, glucagon, and glucocorticoids) and nutrients (especially amino acids, glucose, and fatty acids) act to mediate regulation of mRNA translation in tissues such as liver, heart, and skeletal muscle.
KESTER, MARK, PhD, Distinguished Professor, Department of Pharmacology, and is interested in understanding the mechanism by which mitogenesis is controlled during the inflammatory process.
LANG, CHARLES H., PhD, is Distinguished Professor and Vice-Chairman, Department of Cellular & Molecular Physiology, and studies mechanisms responsible for sepsis-induced changes in the IGF system and how these changes impact rates of muscle protein balance (both protein synthesis and degradation) leading to the erosion of lean body mass.
PORITZ, LISA, MD, Associate Professor of Colorectal Surgery, and studies the biology and pathophysiology of inflammatory injury of the intestinal tract.
REEVES, BRAIN, MD, Professor of Internal Medicine and Chief Division of Nephrology, with a research focus on the role of TNF in the pathogenesis of acute renal failure.