Welcome to X-Ray Crystallography Core Facility
The Protein X-ray Crystallography Core Facility is hosted by the Department of Biochemistry and Molecular Biology. The purpose of the Facility is to provide equipment, training, assistance, and technological innovation for determining 3D atomic structures of proteins and other macromolecules. Services provided by the Facility include: aid in crystallization, x-ray characterization of crystals, x-ray data collection, processing and quality analysis of data, and structure determination and display.
The X-ray Crystallography Core Facility is located on the east side of the 5th floor of the Crescent (Room C5722). It contains a crystallization room, an x-ray enclosure, and a computational area for data collection, data processing, and structure determination. The Crystallization room houses a Douglas Instruments Oryx6 crystallization robot for microbatch crystallization experiments and equipment for more traditional crystallization. Eleven 48-condition, seven 24-condition, three 96-condition Hampton Screens, and six 96-condition Nextal Suites are available. Three vibration free chambers, maintained at 15 ¡ãC, 10 ¡ãC and room temperature are available for storage of trays. An Olympus SZ-61 microscopes for inspecting crystal trays is also housed here. The x-ray enclosure houses an R-Axis IV++ mounted on a Rigaku Micromax-007 x-ray generator. The x-ray beam is focused by Confocal Blue mirrors. An Xstream 2000 cryostat is also maintained. This Facility is kept at 25 ¡ãC by two independent air conditioning systems. The computing area contains two Dell Dimension PCs (Pentium IV, CPU 3.00GHz) used for data collection and data processing, and a Silicon Graphics Octane workstation for structure determination, visualization and refinement. Standard crystallographic software is freely accessible for use in this facility.
SGI Altix 350 Server is based on 64-bit Linux operating system. It consists of 8 x 1.5 Ghz Intel Itanium 2 processors sharing 8 GB of memory.
The Medical Minute: Enterovirus D68 expected to fade away into winter
Late every summer and into every fall, enteroviruses bring a host of unpleasant ailments. This year, Enterovirus D68 (EV-D68) has been making headlines for its potentially severe symptoms in children, causing some alarm among parents.More...
Mets earns top educator honors with SEA/Duke Award
Dr. Berend Mets, Eric A. Walker Professor and chairman of anesthesiology at Penn State Hershey, has earned top educator honors by receiving the Society for Education in Anesthesia SEA/Duke Award.More...
Drop Your Drawers celebrates life-changing weight loss
Penn State Hershey Surgical Weight Loss held its annual Fall Social and Drop Your Drawers event Oct. 16. Patients and guests enjoyed an evening celebrating the life-changing outcomes that surgical weight loss procedures can help to facilitate.More...
Lecture to focus on understanding safety, quality at the unit level
Jan Jacobs, safety consultant with Ascension, will present “Safety and Quality at the Unit Level” at noon Friday, Oct. 24, in Lecture Room D on the Penn State Hershey campus. Faculty, staff and students are encouraged to attend this lecture being held in conjunction with Healthcare Quality Week (Oct. 19 to 25).More...